Search Results

Overview

Uniprot ID	P08621
Protein Name	U1 small nuclear ribonucleoprotein 70 kDa
Gene Name	SNRNP70
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
130	FEVYGPIKRIHMVYS

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158)

Protein Sequence

10 MTQFLPPNLL 20 ALFAPRDPIP 30 YLPPLEKLPH 40 EKHHNQPYCG 50 IAPYIREFED 60 PRDAPPPTRA 70 ETREERMERK 80 RREKIERRQQ 90 EVETELKMWD 100 PHNDPNAQGD 110 AFKTLFVARV 120 NYDTTESKLR 130 REFEVYGPIK 140 RIHMVYSKRS 150 GKPRGYAFIE 160 YEHERDMHSA 170 YKHADGKKID 180 GRRVLVDVER 190 GRTVKGWRPR 200 RLGGGLGGTR 210 RGGADVNIRH 220 SGRDDTSRYD 230 ERPGPSPLPH 240 RDRDRDRERE 250 RRERSRERDK 260 ERERRRSRSR 270 DRRRRSRSRD 280 KEERRRSRER 290 SKDKDRDRKR 300 RSSRSRERAR 310 RERERKEELR 320 GGGGDMAEPS 330 EAGDAPPDDG 340 PPGELGPDGP 350 DGPEEKGRDR 360 DRERRRSHRS 370 ERERRRDRDR 380 DRDRDREHKR 390 GERGSERGRD 400 EARGGGGGQD 410 NGLEGLGNDS 420 RDMYMESEGG 430 DGYLAPENGY LMEAAPE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0043202	lysosomal lumen
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005681	spliceosomal complex
Cellular Component	GO:0005685	U1 snRNP
Cellular Component	GO:0071004	U2-type prespliceosome
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0030619	U1 snRNA binding
Molecular Function	GO:1990446	U1 snRNP binding
Biological Process	GO:0071300	cellular response to retinoic acid
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:1904715	negative regulation of chaperone-mediated autophagy
Biological Process	GO:0061084	negative regulation of protein refolding
Biological Process	GO:0043484	regulation of RNA splicing
Biological Process	GO:0000387	spliceosomal snRNP assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.