Overview
| Uniprot ID | P08631 |
|---|
| Protein Name | Tyrosine-protein kinase HCK |
|---|
| Gene Name | HCK |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 248 |
CMSSKPQKPWEKDAW |
Function
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS
Protein Sequence
10
MGGRSSCEDP
20
GCPRDEERAP
30
RMGCMKSKFL
40
QVGGNTFSKT
50
ETSASPHCPV
60
YVPDPTSTIK
70
PGPNSHNSNT
80
PGIREAGSED
90
IIVVALYDYE
100
AIHHEDLSFQ
110
KGDQMVVLEE
120
SGEWWKARSL
130
ATRKEGYIPS
140
NYVARVDSLE
150
TEEWFFKGIS
160
RKDAERQLLA
170
PGNMLGSFMI
180
RDSETTKGSY
190
SLSVRDYDPR
200
QGDTVKHYKI
210
RTLDNGGFYI
220
SPRSTFSTLQ
230
ELVDHYKKGN
240
DGLCQKLSVP
250
CMSSKPQKPW
260
EKDAWEIPRE
270
SLKLEKKLGA
280
GQFGEVWMAT
290
YNKHTKVAVK
300
TMKPGSMSVE
310
AFLAEANVMK
320
TLQHDKLVKL
330
HAVVTKEPIY
340
IITEFMAKGS
350
LLDFLKSDEG
360
SKQPLPKLID
370
FSAQIAEGMA
380
FIEQRNYIHR
390
DLRAANILVS
400
ASLVCKIADF
410
GLARVIEDNE
420
YTAREGAKFP
430
IKWTAPEAIN
440
FGSFTIKSDV
450
WSFGILLMEI
460
VTYGRIPYPG
470
MSNPEVIRAL
480
ERGYRMPRPE
490
NCPEELYNIM
500
MRCWKNRPEE
510
RPTFEYIQSV
520
LDDFYTATES
QYQQQP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005901 |
caveola |
| Cellular Component |
GO:0042995 |
cell projection |
| Cellular Component |
GO:0009898 |
cytoplasmic side of plasma membrane |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030133 |
transport vesicle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
| Molecular Function |
GO:0001784 |
phosphotyrosine residue binding |
| Molecular Function |
GO:0004713 |
protein tyrosine kinase activity |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0007169 |
cell surface receptor protein tyrosine kinase signaling pathway |
| Biological Process |
GO:0019221 |
cytokine-mediated signaling pathway |
| Biological Process |
GO:0038096 |
Fc-gamma receptor signaling pathway involved in phagocytosis |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0002758 |
innate immune response-activating signaling pathway |
| Biological Process |
GO:0007229 |
integrin-mediated signaling pathway |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0043299 |
leukocyte degranulation |
| Biological Process |
GO:0002522 |
leukocyte migration involved in immune response |
| Biological Process |
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
| Biological Process |
GO:0007498 |
mesoderm development |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0002862 |
negative regulation of inflammatory response to antigenic stimulus |
| Biological Process |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
| Biological Process |
GO:0030838 |
positive regulation of actin filament polymerization |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0046777 |
protein autophosphorylation |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0032956 |
regulation of actin cytoskeleton organization |
| Biological Process |
GO:0008360 |
regulation of cell shape |
| Biological Process |
GO:0050727 |
regulation of inflammatory response |
| Biological Process |
GO:0050764 |
regulation of phagocytosis |
| Biological Process |
GO:0071801 |
regulation of podosome assembly |
| Biological Process |
GO:0045728 |
respiratory burst after phagocytosis |
| Biological Process |
GO:0060333 |
type II interferon-mediated signaling pathway |
Reference
PMID: N/A