Search Results

Overview

Uniprot IDP08651
Protein NameNuclear factor 1 C-type
Gene NameNFIC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
280 STSSSGSKRHKSGSM

Function

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Promotes telomerase reverse transcriptase transcription (PubMed:35198878)

Protein Sequence

10 MYSSPLCLTQ 20 DEFHPFIEAL 30 LPHVRAFAYT 40 WFNLQARKRK 50 YFKKHEKRMS 60 KDEERAVKDE 70 LLGEKPEVKQ 80 KWASRLLAKL 90 RKDIRPECRE 100 DFVLSITGKK 110 APGCVLSNPD 120 QKGKMRRIDC 130 LRQADKVWRL 140 DLVMVILFKG 150 IPLESTDGER 160 LVKAAQCGHP 170 VLCVQPHHIG 180 VAVKELDLYL 190 AYFVRERDAE 200 QSGSPRTGMG 210 SDQEDSKPIT 220 LDTTDFQESF 230 VTSGVFSVTE 240 LIQVSRTPVV 250 TGTGPNFSLG 260 ELQGHLAYDL 270 NPASTGLRRT 280 LPSTSSSGSK 290 RHKSGSMEED 300 VDTSPGGDYY 310 TSPSSPTSSS 320 RNWTEDMEGG 330 ISSPVKKTEM 340 DKSPFNSPSP 350 QDSPRLSSFT 360 QHHRPVIAVH 370 SGIARSPHPS 380 SALHFPTTSI 390 LPQTASTYFP 400 HTAIRYPPHL 410 NPQDPLKDLV 420 SLACDPASQQ 430 PGPLNGSGQL 440 KMPSHCLSAQ 450 MLAPPPPGLP 460 RLALPPATKP 470 ATTSEGGATS 480 PTSPSYSPPD 490 TSPANRSFVG 500 LGPRDPAGIY QAQSWYLG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0006260 DNA replication
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.