Search Results

Overview

Uniprot IDP08729
Protein NameKeratin, type II cytoskeletal 7
Gene NameKRT7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 QIKTLNNKFASFIDK
117 RFLEQQNKLLETKWT
122 QNKLLETKWTLLQEQ
130 WTLLQEQKSAKSSRL
179 VVEDFKNKYEDEINH
198 ENEFVVLKKDVDAAY
199 NEFVVLKKDVDAAYM
273 AQYEEMAKCSRAEAE
296 TLQAQAGKHGDDLRN
326 QAEIDNIKNQRAKLE
331 NIKNQRAKLEAAIAE
348 ERGELALKDARAKQE
353 ALKDARAKQEELEAA
394 IEIATYRKLLEGEES

Function

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)

Protein Sequence

10 MSIHFSSPVF 20 TSRSAAFSGR 30 GAQVRLSSAR 40 PGGLGSSSLY 50 GLGASRPRVA 60 VRSAYGGPVG 70 AGIREVTINQ 80 SLLAPLRLDA 90 DPSLQRVRQE 100 ESEQIKTLNN 110 KFASFIDKVR 120 FLEQQNKLLE 130 TKWTLLQEQK 140 SAKSSRLPDI 150 FEAQIAGLRG 160 QLEALQVDGG 170 RLEAELRSMQ 180 DVVEDFKNKY 190 EDEINHRTAA 200 ENEFVVLKKD 210 VDAAYMSKVE 220 LEAKVDALND 230 EINFLRTLNE 240 TELTELQSQI 250 SDTSVVLSMD 260 NSRSLDLDGI 270 IAEVKAQYEE 280 MAKCSRAEAE 290 AWYQTKFETL 300 QAQAGKHGDD 310 LRNTRNEISE 320 MNRAIQRLQA 330 EIDNIKNQRA 340 KLEAAIAEAE 350 ERGELALKDA 360 RAKQEELEAA 370 LQRGKQDMAR 380 QLREYQELMS 390 VKLALDIEIA 400 TYRKLLEGEE 410 SRLAGDGVGA 420 VNISVMNSTG 430 GSSSGGGIGL 440 TLGGTMGSNA 450 LSFSSSAGPG 460 LLKAYSIRTA SASRRSARD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0045095 keratin filament
Cellular Component GO:0005634 nucleus
Molecular Function GO:0030280 structural constituent of skin epidermis
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0031424 keratinization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.