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Overview

Uniprot IDP08835
Protein NameAlbumin
Gene NameALB
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
228 LKCASIQKFGERAFK
266 TDLAKVHKECCHGDL
299 DTISTKLKECCDKPL
304 KLKECCDKPLLEKSH
489 RLCVLHEKTPVSEKV
495 EKTPVSEKVTKCCTE
498 PVSEKVTKCCTESLV
548 EDEKQIKKQTALVEL

Function

Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity)

Protein Sequence

10 MKWVTFISLL 20 FLFSSAYSRG 30 VFRRDTYKSE 40 IAHRFKDLGE 50 QYFKGLVLIA 60 FSQHLQQCPY 70 EEHVKLVREV 80 TEFAKTCVAD 90 ESAENCDKSI 100 HTLFGDKLCA 110 IPSLREHYGD 120 LADCCEKEEP 130 ERNECFLQHK 140 NDNPDIPKLK 150 PDPVALCADF 160 QEDEQKFWGK 170 YLYEIARRHP 180 YFYAPELLYY 190 AIIYKDVFSE 200 CCQAADKAAC 210 LLPKIEHLRE 220 KVLTSAAKQR 230 LKCASIQKFG 240 ERAFKAWSLA 250 RLSQRFPKAD 260 FTEISKIVTD 270 LAKVHKECCH 280 GDLLECADDR 290 ADLAKYICEN 300 QDTISTKLKE 310 CCDKPLLEKS 320 HCIAEAKRDE 330 LPADLNPLEH 340 DFVEDKEVCK 350 NYKEAKHVFL 360 GTFLYEYSRR 370 HPDYSVSLLL 380 RIAKIYEATL 390 EDCCAKEDPP 400 ACYATVFDKF 410 QPLVDEPKNL 420 IKQNCELFEK 430 LGEYGFQNAL 440 IVRYTKKVPQ 450 VSTPTLVEVA 460 RKLGLVGSRC 470 CKRPEEERLS 480 CAEDYLSLVL 490 NRLCVLHEKT 500 PVSEKVTKCC 510 TESLVNRRPC 520 FSALTPDETY 530 KPKEFVEGTF 540 TFHADLCTLP 550 EDEKQIKKQT 560 ALVELLKHKP 570 HATEEQLRTV 580 LGNFAAFVQK 590 CCAAPDHEAC 600 FAVEGPKFVI EIRGILA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:1903981 enterobactin binding
Molecular Function GO:0005504 fatty acid binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Molecular Function GO:0036094 small molecule binding
Molecular Function GO:0015643 toxic substance binding
Biological Process GO:0072732 cellular response to calcium ion starvation
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0051902 negative regulation of mitochondrial depolarization
Biological Process GO:0031667 response to nutrient levels

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.