Search Results
Overview
| Uniprot ID | P09104 |
|---|---|
| Protein Name | Gamma-enolase |
| Gene Name | ENO2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 193 | AEVYHTLKGVIKDKY |
| 256 | SEFYRDGKYDLDFKS |
| 335 | IERAVEEKACNCLLL |
| 5 | ***MSIEKIWAREIL |
Function
Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity)
Protein Sequence
10
MSIEKIWARE
20
ILDSRGNPTV
30
EVDLYTAKGL
40
FRAAVPSGAS
50
TGIYEALELR
60
DGDKQRYLGK
70
GVLKAVDHIN
80
STIAPALISS
90
GLSVVEQEKL
100
DNLMLELDGT
110
ENKSKFGANA
120
ILGVSLAVCK
130
AGAAERELPL
140
YRHIAQLAGN
150
SDLILPVPAF
160
NVINGGSHAG
170
NKLAMQEFMI
180
LPVGAESFRD
190
AMRLGAEVYH
200
TLKGVIKDKY
210
GKDATNVGDE
220
GGFAPNILEN
230
SEALELVKEA
240
IDKAGYTEKI
250
VIGMDVAASE
260
FYRDGKYDLD
270
FKSPTDPSRY
280
ITGDQLGALY
290
QDFVRDYPVV
300
SIEDPFDQDD
310
WAAWSKFTAN
320
VGIQIVGDDL
330
TVTNPKRIER
340
AVEEKACNCL
350
LLKVNQIGSV
360
TEAIQACKLA
370
QENGWGVMVS
380
HRSGETEDTF
390
IADLVVGLCT
400
GQIKTGAPCR
410
SERLAKYNQL
420
MRIEEELGDE
430
ARFAGHNFRN
PSVL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0000015 | phosphopyruvate hydratase complex |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004634 | phosphopyruvate hydratase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.