Search Results

Overview

Uniprot IDP09110
Protein Name3-ketoacyl-CoA thiolase, peroxisomal
Gene NameACAA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
198 RFGISREKQDTFALA
209 FALASQQKAARAQSK
216 KAARAQSKGCFQAEI
234 TTTVHDDKGTKRSIT
237 VHDDKGTKRSITVTQ
259 TTMEGLAKLKPAFKK
266 KLKPAFKKDGSTTAG
292 ILLARRSKAEELGLP
365 KLRLPPEKVNPLGGA
395 ITLLNELKRRGKRAY

Function

Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:11734571, PubMed:2882519). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:11734571, PubMed:2882519). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:11734571, PubMed:2882519). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes

Protein Sequence

10 MQRLQVVLGH 20 LRGPADSGWM 30 PQAAPCLSGA 40 PQASAADVVV 50 VHGRRTAICR 60 AGRGGFKDTT 70 PDELLSAVMT 80 AVLKDVNLRP 90 EQLGDICVGN 100 VLQPGAGAIM 110 ARIAQFLSDI 120 PETVPLSTVN 130 RQCSSGLQAV 140 ASIAGGIRNG 150 SYDIGMACGV 160 ESMSLADRGN 170 PGNITSRLME 180 KEKARDCLIP 190 MGITSENVAE 200 RFGISREKQD 210 TFALASQQKA 220 ARAQSKGCFQ 230 AEIVPVTTTV 240 HDDKGTKRSI 250 TVTQDEGIRP 260 STTMEGLAKL 270 KPAFKKDGST 280 TAGNSSQVSD 290 GAAAILLARR 300 SKAEELGLPI 310 LGVLRSYAVV 320 GVPPDIMGIG 330 PAYAIPVALQ 340 KAGLTVSDVD 350 IFEINEAFAS 360 QAAYCVEKLR 370 LPPEKVNPLG 380 GAVALGHPLG 390 CTGARQVITL 400 LNELKRRGKR 410 AYGVVSMCIG 420 TGMGAAAVFE YPGN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0016020 membrane
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005777 peroxisome
Cellular Component GO:0035580 specific granule lumen
Molecular Function GO:0008775 acetate CoA-transferase activity
Molecular Function GO:0003985 acetyl-CoA C-acetyltransferase activity
Molecular Function GO:0003988 acetyl-CoA C-acyltransferase activity
Molecular Function GO:0050633 acetyl-CoA C-myristoyltransferase activity
Molecular Function GO:0120524 long-chain fatty acyl-CoA oxidase activity
Biological Process GO:0036109 alpha-linolenic acid metabolic process
Biological Process GO:0008206 bile acid metabolic process
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
Biological Process GO:0010124 phenylacetate catabolic process
Biological Process GO:0000038 very long-chain fatty acid metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.