Search Results
Overview
| Uniprot ID | P09132 |
|---|---|
| Protein Name | Signal recognition particle 19 kDa protein |
| Gene Name | SRP19 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | KLKTRTQKTGGADQS |
| 136 | LQQGEGSKKGKGKKK |
| 87 | GRVRVQLKQEDGSLC |
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048500 | signal recognition particle |
| Cellular Component | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting |
| Molecular Function | GO:0008312 | 7S RNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006613 | cotranslational protein targeting to membrane |
| Biological Process | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.