Search Results
Overview
| Uniprot ID | P09210 |
|---|---|
| Protein Name | Glutathione S-transferase A2 |
| Gene Name | GSTA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | KLALIQEKTKNRYFP |
| 138 | RYFPAFEKVLKSHGQ |
| 141 | PAFEKVLKSHGQDYL |
| 152 | QDYLVGNKLSRADIH |
| 195 | ISNLPTVKKFLQPGS |
| 196 | SNLPTVKKFLQPGSP |
| 205 | LQPGSPRKPPMDEKS |
| 36 | EFEEKFIKSAEDLDK |
| 43 | KSAEDLDKLRNDGYL |
| 6 | **MAEKPKLHYSNIR |
| 78 | ILNYIASKYNLYGKD |
| 84 | SKYNLYGKDIKEKAL |
Function
Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds
Protein Sequence
10
MAEKPKLHYS
20
NIRGRMESIR
30
WLLAAAGVEF
40
EEKFIKSAED
50
LDKLRNDGYL
60
MFQQVPMVEI
70
DGMKLVQTRA
80
ILNYIASKYN
90
LYGKDIKEKA
100
LIDMYIEGIA
110
DLGEMILLLP
120
FSQPEEQDAK
130
LALIQEKTKN
140
RYFPAFEKVL
150
KSHGQDYLVG
160
NKLSRADIHL
170
VELLYYVEEL
180
DSSLISSFPL
190
LKALKTRISN
200
LPTVKKFLQP
210
GSPRKPPMDE
220
KSLEESRKIF
RF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.