Search Results
Overview
| Uniprot ID | P09211 |
|---|---|
| Protein Name | Glutathione S-transferase P |
| Gene Name | GSTP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | KALPGQLKPFETLLS |
| 30 | ADQGQSWKEEVVTVE |
Function
Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1540159, PubMed:1567427, PubMed:8433974). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde (PubMed:38016474). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration (PubMed:21668448)
Protein Sequence
10
MPPYTVVYFP
20
VRGRCAALRM
30
LLADQGQSWK
40
EEVVTVETWQ
50
EGSLKASCLY
60
GQLPKFQDGD
70
LTLYQSNTIL
80
RHLGRTLGLY
90
GKDQQEAALV
100
DMVNDGVEDL
110
RCKYISLIYT
120
NYEAGKDDYV
130
KALPGQLKPF
140
ETLLSQNQGG
150
KTFIVGDQIS
160
FADYNLLDLL
170
LIHEVLAPGC
180
LDAFPLLSAY
190
VGRLSARPKL
200
KAFLASPEYV
210
NLPINGNGKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Cellular Component | GO:0097057 | TRAF2-GSTP1 complex |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0035731 | dinitrosyl-iron complex binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0008432 | JUN kinase binding |
| Molecular Function | GO:0070026 | nitric oxide binding |
| Molecular Function | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| Molecular Function | GO:0035730 | S-nitrosoglutathione binding |
| Molecular Function | GO:0015643 | toxic substance binding |
| Biological Process | GO:0031100 | animal organ regeneration |
| Biological Process | GO:0071460 | cellular response to cell-matrix adhesion |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0035726 | common myeloid progenitor cell proliferation |
| Biological Process | GO:1901687 | glutathione derivative biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0051122 | hepoxilin biosynthetic process |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0002674 | negative regulation of acute inflammatory response |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0048147 | negative regulation of fibroblast proliferation |
| Biological Process | GO:0032691 | negative regulation of interleukin-1 beta production |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0070664 | negative regulation of leukocyte proliferation |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production |
| Biological Process | GO:0071672 | negative regulation of smooth muscle cell chemotaxis |
| Biological Process | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032720 | negative regulation of tumor necrosis factor production |
| Biological Process | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway |
| Biological Process | GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0035732 | nitric oxide storage |
| Biological Process | GO:0014003 | oligodendrocyte development |
| Biological Process | GO:0032930 | positive regulation of superoxide anion generation |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0032872 | regulation of stress-activated MAPK cascade |
| Biological Process | GO:0043200 | response to amino acid |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0033591 | response to L-ascorbic acid |
| Biological Process | GO:0000302 | response to reactive oxygen species |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.
[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.