Overview
| Uniprot ID | P09234 |
|---|
| Protein Name | U1 small nuclear ribonucleoprotein C |
|---|
| Gene Name | SNRPC |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 35 |
RKHKENVKDYYQKWM |
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region
Protein Sequence
10
MPKFYCDYCD
20
TYLTHDSPSV
30
RKTHCSGRKH
40
KENVKDYYQK
50
WMEEQAQSLI
60
DKTTAAFQQG
70
KIPPTPFSAP
80
PPAGAMIPPP
90
PSLPGPPRPG
100
MMPAPHMGGP
110
PMMPMMGPPP
120
PGMMPVGPAP
130
GMRPPMGGHM
140
PMMPGPPMMR
150
PPARPMMVPT
RPGMTRPDR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015030 |
Cajal body |
| Cellular Component |
GO:0000243 |
commitment complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005685 |
U1 snRNP |
| Cellular Component |
GO:0071004 |
U2-type prespliceosome |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0030627 |
pre-mRNA 5'-splice site binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0003727 |
single-stranded RNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0000395 |
mRNA 5'-splice site recognition |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0000387 |
spliceosomal snRNP assembly |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.