Search Results
Overview
| Uniprot ID | P09417 |
|---|---|
| Protein Name | Dihydropteridine reductase |
| Gene Name | QDPR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | AKSKSLFKNCDLMWK |
| 124 | ISSHLATKHLKEGGL |
| 127 | HLATKHLKEGGLLTL |
Function
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin
Protein Sequence
10
MAAAAAAGEA
20
RRVLVYGGRG
30
ALGSRCVQAF
40
RARNWWVASV
50
DVVENEEASA
60
SIIVKMTDSF
70
TEQADQVTAE
80
VGKLLGEEKV
90
DAILCVAGGW
100
AGGNAKSKSL
110
FKNCDLMWKQ
120
SIWTSTISSH
130
LATKHLKEGG
140
LLTLAGAKAA
150
LDGTPGMIGY
160
GMAKGAVHQL
170
CQSLAGKNSG
180
MPPGAAAIAV
190
LPVTLDTPMN
200
RKSMPEADFS
210
SWTPLEFLVE
220
TFHDWITGKN
230
RPSSGSLIQV
240
VTTEGRTELT
PAYF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004155 | 6,7-dihydropteridine reductase activity |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0070404 | NADH binding |
| Molecular Function | GO:0070402 | NADPH binding |
| Biological Process | GO:0006520 | amino acid metabolic process |
| Biological Process | GO:0051066 | dihydrobiopterin metabolic process |
| Biological Process | GO:0006559 | L-phenylalanine catabolic process |
| Biological Process | GO:0006729 | tetrahydrobiopterin biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.