Search Results
Overview
| Uniprot ID | P09456 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type I-alpha regulatory subunit |
| Gene Name | Prkar1a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 70 | RQIQSLQKSGIRTDS |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells
Protein Sequence
10
MASGSMAASE
20
EERSLRECEL
30
YVQKHNIQAL
40
LKDSIVQLCT
50
ARPERPMAFL
60
REYFERLEKE
70
EARQIQSLQK
80
SGIRTDSRED
90
EISPPPPNPV
100
VKGRRRRGAI
110
SAEVYTEEDA
120
ASYVRKVIPK
130
DYKTMAALAK
140
AIEKNVLFSH
150
LDDNERSDIF
160
DAMFPVSFIA
170
GETVIQQGDE
180
GDNFYVIDQG
190
EMDVYVNNEW
200
ATSVGEGGSF
210
GELALIYGTP
220
RAATVKAKTN
230
VKLWGIDRDS
240
YRRILMGSTL
250
RKRKMYEEFL
260
SKVSILESLD
270
KWERLTVADA
280
LEPVQFEDGQ
290
KIVVQGEPGD
300
EFFIILEGTA
310
AVLQRRSENE
320
EFVEVGRLGP
330
SDYFGEIALL
340
MNRPRAATVV
350
ARGPLKCVKL
360
DRPRFERVLG
370
PCSDILKRNI
380
QQYNSFVSLS
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0007507 | heart development |
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0031588 | nucleotide-activated protein kinase complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0120212 | sperm head-tail coupling apparatus |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0060038 | cardiac muscle cell proliferation |
| Biological Process | GO:0071377 | cellular response to glucagon stimulus |
| Biological Process | GO:0007143 | female meiotic nuclear division |
| Biological Process | GO:0001707 | mesoderm formation |
| Biological Process | GO:0046007 | negative regulation of activated T cell proliferation |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0045835 | negative regulation of meiotic nuclear division |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:1903538 | regulation of meiotic cell cycle process involved in oocyte maturation |
| Biological Process | GO:0045859 | regulation of protein kinase activity |
| Biological Process | GO:0045214 | sarcomere organization |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.