Search Results

Overview

Uniprot IDP09467
Protein NameFructose-1,6-bisphosphatase 1
Gene NameFBP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 VLVSEEDKHAIIVEP
110 AIIVEPEKRGKYVVC
143 IFGIYRKKSTDEPSE
151 STDEPSEKDALQPGR
269 IFLYPANKKSPNGKL
300 GGMATTGKEAVLDVI
330 DDVLEFLKVYEKHSA
334 EFLKVYEKHSAQ***
51 AISSAVRKAGIAHLY
72 NVTGDQVKKLDVLSN
73 VTGDQVKKLDVLSND

Function

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain

Protein Sequence

10 MADQAPFDTD 20 VNTLTRFVME 30 EGRKARGTGE 40 LTQLLNSLCT 50 AVKAISSAVR 60 KAGIAHLYGI 70 AGSTNVTGDQ 80 VKKLDVLSND 90 LVMNMLKSSF 100 ATCVLVSEED 110 KHAIIVEPEK 120 RGKYVVCFDP 130 LDGSSNIDCL 140 VSVGTIFGIY 150 RKKSTDEPSE 160 KDALQPGRNL 170 VAAGYALYGS 180 ATMLVLAMDC 190 GVNCFMLDPA 200 IGEFILVDKD 210 VKIKKKGKIY 220 SLNEGYARDF 230 DPAVTEYIQR 240 KKFPPDNSAP 250 YGARYVGSMV 260 ADVHRTLVYG 270 GIFLYPANKK 280 SPNGKLRLLY 290 ECNPMAYVME 300 KAGGMATTGK 310 EAVLDVIPTD 320 IHQRAPVILG 330 SPDDVLEFLK VYEKHSAQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016208 AMP binding
Molecular Function GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0048029 monosaccharide binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process GO:0071475 cellular hyperosmotic salinity response
Biological Process GO:0071477 cellular hypotonic salinity response
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0071286 cellular response to magnesium ion
Biological Process GO:1904628 cellular response to phorbol 13-acetate 12-myristate
Biological Process GO:0097403 cellular response to raffinose
Biological Process GO:0071466 cellular response to xenobiotic stimulus
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0006000 fructose metabolic process
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0045820 negative regulation of glycolytic process
Biological Process GO:0046580 negative regulation of Ras protein signal transduction
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0031667 response to nutrient levels

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.