Search Results
Overview
| Uniprot ID | P09488 |
|---|---|
| Protein Name | Glutathione S-transferase Mu 1 |
| Gene Name | GSTM1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | EFEKLKPKYLEELPE |
| 134 | YLEELPEKLKLYSEF |
| 136 | EELPEKLKLYSEFLG |
| 144 | LYSEFLGKRPWFAGN |
| 199 | EKISAYMKSSRFLPR |
| 211 | LPRPVFSKMAVWGNK |
| 31 | TDSSYEEKKYTMGDA |
| 32 | DSSYEEKKYTMGDAP |
| 50 | RSQWLNEKFKLGLDF |
| 83 | ILCYIARKHNLCGET |
| 94 | CGETEEEKIRVDILE |
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276)
Protein Sequence
10
MPMILGYWDI
20
RGLAHAIRLL
30
LEYTDSSYEE
40
KKYTMGDAPD
50
YDRSQWLNEK
60
FKLGLDFPNL
70
PYLIDGAHKI
80
TQSNAILCYI
90
ARKHNLCGET
100
EEEKIRVDIL
110
ENQTMDNHMQ
120
LGMICYNPEF
130
EKLKPKYLEE
140
LPEKLKLYSE
150
FLGKRPWFAG
160
NKITFVDFLV
170
YDVLDLHRIF
180
EPKCLDAFPN
190
LKDFISRFEG
200
LEKISAYMKS
210
SRFLPRPVFS
KMAVWGNK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0043295 | glutathione binding |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0070458 | cellular detoxification of nitrogen compound |
| Biological Process | GO:1901687 | glutathione derivative biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0051122 | hepoxilin biosynthetic process |
| Biological Process | GO:0018916 | nitrobenzene metabolic process |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.