Search Results

Overview

Uniprot IDP09495
Protein NameTropomyosin alpha-4 chain
Gene NameTpm4
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
11 LNSLEAVKRKIQALQ
116 EMQLKEAKHIAEEAD
13 SLEAVKRKIQALQQQ
153 RAEVSELKSSDLEEE
169 KNVTNNLKSLEAASE
177 SLEAASEKYSEKEDK
181 ASEKYSEKEDKYEEE
195 EIKLLSDKLKEAETR
212 FAERTVSKLEKTIDD
215 RTVSKLEKTIDDLEE
223 TIDDLEEKLAQAKEE
44 GERERREKAEGDAAA

Function

Binds to actin filaments in muscle and non-muscle cells (PubMed:7568216). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (By similarity). Smooth muscle contraction is regulated by interaction with caldesmon (By similarity). In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (By similarity). Plays a role in platelet biogenesis

Protein Sequence

10 MAGLNSLEAV 20 KRKIQALQQQ 30 ADDAEDRAQG 40 LQRELDGERE 50 RREKAEGDAA 60 ALNRRIQLVE 70 EELDRAQERL 80 ATALQKLEEA 90 EKAADESERG 100 MKVIENRAMK 110 DEEKMEIQEM 120 QLKEAKHIAE 130 EADRKYEEVA 140 RKLVILEGEL 150 ERAEERAEVS 160 ELKSSDLEEE 170 LKNVTNNLKS 180 LEAASEKYSE 190 KEDKYEEEIK 200 LLSDKLKEAE 210 TRAEFAERTV 220 SKLEKTIDDL 230 EEKLAQAKEE 240 NVGLHQTLDQ TLNELNCI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005884 actin filament
Cellular Component GO:0030863 cortical cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0002102 podosome
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0007015 actin filament organization
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030220 platelet formation

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.