Search Results

Overview

Uniprot IDP09496
Protein NameClathrin light chain A
Gene NameCLTA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
136 RKQEAEWKEKAIKEL
223 RLCDFNPKSSKQAKD
242 RSVLISLKQAPLVH*

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582)

Protein Sequence

10 MAELDPFGAP 20 AGAPGGPALG 30 NGVAGAGEED 40 PAAAFLAQQE 50 SEIAGIENDE 60 AFAILDGGAP 70 GPQPHGEPPG 80 GPDAVDGVMN 90 GEYYQESNGP 100 TDSYAAISQV 110 DRLQSEPESI 120 RKWREEQMER 130 LEALDANSRK 140 QEAEWKEKAI 150 KELEEWYARQ 160 DEQLQKTKAN 170 NRVADEAFYK 180 QPFADVIGYV 190 TNINHPCYSL 200 EQAAEEAFVN 210 DIDESSPGTE 220 WERVARLCDF 230 NPKSSKQAKD 240 VSRMRSVLIS LKQAPLVH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030118 clathrin coat
Cellular Component GO:0030132 clathrin coat of coated pit
Cellular Component GO:0030130 clathrin coat of trans-Golgi network vesicle
Cellular Component GO:0071439 clathrin complex
Cellular Component GO:0030125 clathrin vesicle coat
Cellular Component GO:0045334 clathrin-coated endocytic vesicle
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0036020 endolysosome membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0005764 lysosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098843 postsynaptic endocytic zone
Cellular Component GO:0098835 presynaptic endocytic zone membrane
Cellular Component GO:0005819 spindle
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0032588 trans-Golgi network membrane
Molecular Function GO:0032050 clathrin heavy chain binding
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0042277 peptide binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0051301 cell division
Biological Process GO:0048268 clathrin coat assembly
Biological Process GO:0072583 clathrin-dependent endocytosis
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0048488 synaptic vesicle endocytosis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.