Search Results

Overview

Uniprot ID	P09497
Protein Name	Clathrin light chain B
Gene Name	CLTB
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
204	QLCDFNPKSSKQCKD
223	RSVLMSLKQTPLSR*

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

Protein Sequence

10 MADDFGFFSS 20 SESGAPEAAE 30 EDPAAAFLAQ 40 QESEIAGIEN 50 DEGFGAPAGS 60 HAAPAQPGPT 70 SGAGSEDMGT 80 TVNGDVFQEA 90 NGPADGYAAI 100 AQADRLTQEP 110 ESIRKWREEQ 120 RKRLQELDAA 130 SKVTEQEWRE 140 KAKKDLEEWN 150 QRQSEQVEKN 160 KINNRIADKA 170 FYQQPDADII 180 GYVASEEAFV 190 KESKEETPGT 200 EWEKVAQLCD 210 FNPKSSKQCK 220 DVSRLRSVLM SLKQTPLSR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0060170	ciliary membrane
Cellular Component	GO:0030118	clathrin coat
Cellular Component	GO:0030132	clathrin coat of coated pit
Cellular Component	GO:0030130	clathrin coat of trans-Golgi network vesicle
Cellular Component	GO:0030125	clathrin vesicle coat
Cellular Component	GO:0045334	clathrin-coated endocytic vesicle
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098835	presynaptic endocytic zone membrane
Cellular Component	GO:0030672	synaptic vesicle membrane
Cellular Component	GO:0005802	trans-Golgi network
Molecular Function	GO:0032050	clathrin heavy chain binding
Molecular Function	GO:0042277	peptide binding
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0072583	clathrin-dependent endocytosis
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0048488	synaptic vesicle endocytosis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.