Search Results

Overview

Uniprot IDP09525
Protein NameAnnexin A4
Gene NameANXA4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 QELRRAMKGAGTDEG
184 DLYEAGEKKWGTDEV
185 LYEAGEKKWGTDEVK
213 LHVFDEYKRISQKDI
218 EYKRISQKDIEQSIK
246 IVKCMRNKSAYFAEK
253 KSAYFAEKLYKSMKG
259 EKLYKSMKGLGTDDN
28 QTLRKAMKGLGTDED
293 HFKRLYGKSLYSFIK
300 KSLYSFIKGDTSGDY
4 ****MATKGGTVKAA
57 QEIRTAYKSTIGRDL
9 ATKGGTVKAASGFNA

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis

Protein Sequence

10 MATKGGTVKA 20 ASGFNAMEDA 30 QTLRKAMKGL 40 GTDEDAIISV 50 LAYRNTAQRQ 60 EIRTAYKSTI 70 GRDLIDDLKS 80 ELSGNFEQVI 90 VGMMTPTVLY 100 DVQELRRAMK 110 GAGTDEGCLI 120 EILASRTPEE 130 IRRISQTYQQ 140 QYGRSLEDDI 150 RSDTSFMFQR 160 VLVSLSAGGR 170 DEGNYLDDAL 180 VRQDAQDLYE 190 AGEKKWGTDE 200 VKFLTVLCSR 210 NRNHLLHVFD 220 EYKRISQKDI 230 EQSIKSETSG 240 SFEDALLAIV 250 KCMRNKSAYF 260 AEKLYKSMKG 270 LGTDDNTLIR 280 VMVSRAEIDM 290 LDIRAHFKRL 300 YGKSLYSFIK 310 GDTSGDYRKV LLVLCGGDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0012506 vesicle membrane
Cellular Component GO:0042589 zymogen granule membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051059 NF-kappaB binding
Molecular Function GO:0001786 phosphatidylserine binding
Molecular Function GO:0004859 phospholipase inhibitor activity
Molecular Function GO:0140416 transcription regulator inhibitor activity
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:0032717 negative regulation of interleukin-8 production
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0007165 signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.