Overview
| Uniprot ID | P09527 |
|---|
| Protein Name | Ras-related protein Rab-7a |
|---|
| Gene Name | Rab7a |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 32 |
MNQYVNKKFSNQYKA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Also plays a central role in growth-factor-mediated cell signaling, nutrient-transporter-mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:16040606). Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:16306406). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Required for vesicular trafficking and cell surface expression of ACE2 (By similarity). May play a role in PRPH neuronal intermediate filament assembly (By similarity)
Protein Sequence
10
MTSRKKVLLK
20
VIILGDSGVG
30
KTSLMNQYVN
40
KKFSNQYKAT
50
IGADFLTKEV
60
MVDDRLVTMQ
70
IWDTAGQERF
80
QSLGVAFYRG
90
ADCCVLVFDV
100
TAPNTFKTLD
110
SWRDEFLIQA
120
SPRDPENFPF
130
VVLGNKIDLE
140
NRQVATKRAQ
150
AWCYSKNNIP
160
YFETSAKEAI
170
NVEQAFQTIA
180
RNALKQETEV
190
ELYNEFPEPI
200
KLDKNERAKA
SAESCSC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097208 |
alveolar lamellar body |
| Cellular Component |
GO:0000421 |
autophagosome membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0070382 |
exocytic vesicle |
| Cellular Component |
GO:0005770 |
late endosome |
| Cellular Component |
GO:0031902 |
late endosome membrane |
| Cellular Component |
GO:0005811 |
lipid droplet |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0033162 |
melanosome membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0045335 |
phagocytic vesicle |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Cellular Component |
GO:0034045 |
phagophore assembly site membrane |
| Cellular Component |
GO:0098830 |
presynaptic endosome |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0030904 |
retromer complex |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Cellular Component |
GO:0043195 |
terminal bouton |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:1905394 |
retromer complex binding |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Molecular Function |
GO:0032935 |
sterol sensor activity |
| Biological Process |
GO:0000045 |
autophagosome assembly |
| Biological Process |
GO:0045453 |
bone resorption |
| Biological Process |
GO:0042632 |
cholesterol homeostasis |
| Biological Process |
GO:0045022 |
early endosome to late endosome transport |
| Biological Process |
GO:0008333 |
endosome to lysosome transport |
| Biological Process |
GO:0099638 |
endosome to plasma membrane protein transport |
| Biological Process |
GO:0007174 |
epidermal growth factor catabolic process |
| Biological Process |
GO:0016042 |
lipid catabolic process |
| Biological Process |
GO:0061724 |
lipophagy |
| Biological Process |
GO:0090120 |
lysosome to ER cholesterol transport |
| Biological Process |
GO:1903542 |
negative regulation of exosomal secretion |
| Biological Process |
GO:0090383 |
phagosome acidification |
| Biological Process |
GO:0090385 |
phagosome-lysosome fusion |
| Biological Process |
GO:1903543 |
positive regulation of exosomal secretion |
| Biological Process |
GO:0045732 |
positive regulation of protein catabolic process |
| Biological Process |
GO:0048524 |
positive regulation of viral process |
| Biological Process |
GO:0061462 |
protein localization to lysosome |
| Biological Process |
GO:0006622 |
protein targeting to lysosome |
| Biological Process |
GO:0022615 |
protein to membrane docking |
| Biological Process |
GO:0009617 |
response to bacterium |
| Biological Process |
GO:0042147 |
retrograde transport, endosome to Golgi |
| Biological Process |
GO:0036466 |
synaptic vesicle recycling via endosome |
| Biological Process |
GO:0019076 |
viral release from host cell |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.