Search Results
Overview
| Uniprot ID | P09528 |
|---|---|
| Protein Name | Ferritin heavy chain |
| Gene Name | Fth1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 69 | EEREHAEKLMKLQNQ |
Function
Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (PubMed:19154717). Mediates iron uptake in capsule cells of the developing kidney (PubMed:19154717). Degraded to release iron upon autophagy activation by nutrient starvation (PubMed:25327288)
Protein Sequence
10
MTTASPSQVR
20
QNYHQDAEAA
30
INRQINLELY
40
ASYVYLSMSC
50
YFDRDDVALK
60
NFAKYFLHQS
70
HEEREHAEKL
80
MKLQNQRGGR
90
IFLQDIKKPD
100
RDDWESGLNA
110
MECALHLEKS
120
VNQSLLELHK
130
LATDKNDPHL
140
CDFIETYYLS
150
EQVKSIKELG
160
DHVTNLRKMG
170
APEAGMAEYL
180
FDKHTLGHGD
ES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044754 | autolysosome |
| Cellular Component | GO:0005776 | autophagosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0071682 | endocytic vesicle lumen |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008199 | ferric iron binding |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Molecular Function | GO:0004322 | ferroxidase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0006826 | iron ion transport |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0048147 | negative regulation of fibroblast proliferation |
| Biological Process | GO:0051259 | protein complex oligomerization |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.