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Overview

Uniprot IDP09542
Protein NameMyosin light chain 3
Gene NameMyl3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
109 LRVLGKPKQEELNSK
134 LQHISKNKDTGTYED
19 DAKAAAPKAAPAPAA
42 APEPERPKEAEFDAS
50 EAEFDASKIKIEFTP
79 RTPKGEMKITYGQCG

Function

Regulatory light chain of myosin. Does not bind calcium

Protein Sequence

10 MAPKKPEPKK 20 DDAKAAAPKA 30 APAPAAAPAA 40 APAAAPEPER 50 PKEAEFDASK 60 IKIEFTPEQI 70 EEFKEAFLLF 80 DRTPKGEMKI 90 TYGQCGDVLR 100 ALGQNPTQAE 110 VLRVLGKPKQ 120 EELNSKMMDF 130 ETFLPMLQHI 140 SKNKDTGTYE 150 DFVEGLRVFD 160 KEGNGTVMGA 170 ELRHVLATLG 180 ERLTEDEVEK 190 LMAGQEDSNG 200 CINYEAFVKH IMAS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031672 A band
Cellular Component GO:0031674 I band
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0016460 myosin II complex
Cellular Component GO:0016461 unconventional myosin complex
Molecular Function GO:0003785 actin monomer binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0003774 cytoskeletal motor activity
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0030049 muscle filament sliding
Biological Process GO:0006942 regulation of striated muscle contraction
Biological Process GO:0002026 regulation of the force of heart contraction
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.