Search Results

Overview

Uniprot IDP09543
Protein Name2',3'-cyclic-nucleotide 3'-phosphodiesterase
Gene NameCNP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 GAFSEEYKRLDEDLA
162 RLDCAQLKEKNQWQL
164 DCAQLKEKNQWQLSA
175 QLSADDLKKLKPGLE
176 LSADDLKKLKPGLEK
178 ADDLKKLKPGLEKDF
204 KSSETLRKAGQVFLE
217 LEELGNHKAFKKELR
235 PGDEPREKMDLVTYF
255 GVLHCTTKFCDYGKA
261 TKFCDYGKAPGAEEY
27 KMSSSGAKDKPELQF
275 YAQQDVLKKSYSKAF
29 SSSGAKDKPELQFPF
316 LWPSDVDKLSPTDNL
371 VGELSRGKLYSLGNG
402 TGYYGKGKPVPTQGS
63 RGLPGSGKSTLARVI
73 LARVIVDKYRDGTKM
79 DKYRDGTKMVSADAY
8 MNRGFSRKSHTFLPK
87 MVSADAYKITPGARG

Function

Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions (PubMed:38117830)

Protein Sequence

10 MNRGFSRKSH 20 TFLPKIFFRK 30 MSSSGAKDKP 40 ELQFPFLQDE 50 DTVATLLECK 60 TLFILRGLPG 70 SGKSTLARVI 80 VDKYRDGTKM 90 VSADAYKITP 100 GARGAFSEEY 110 KRLDEDLAAY 120 CRRRDIRILV 130 LDDTNHERER 140 LEQLFEMADQ 150 YQYQVVLVEP 160 KTAWRLDCAQ 170 LKEKNQWQLS 180 ADDLKKLKPG 190 LEKDFLPLYF 200 GWFLTKKSSE 210 TLRKAGQVFL 220 EELGNHKAFK 230 KELRQFVPGD 240 EPREKMDLVT 250 YFGKRPPGVL 260 HCTTKFCDYG 270 KAPGAEEYAQ 280 QDVLKKSYSK 290 AFTLTISALF 300 VTPKTTGARV 310 ELSEQQLQLW 320 PSDVDKLSPT 330 DNLPRGSRAH 340 ITLGCAADVE 350 AVQTGLDLLE 360 ILRQEKGGSR 370 GEEVGELSRG 380 KLYSLGNGRW 390 MLTLAKNMEV 400 RAIFTGYYGK 410 GKPVPTQGSR 420 KGGALQSCTI I

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0009214 cyclic nucleotide catabolic process
Biological Process GO:0021762 substantia nigra development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.