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Overview

Uniprot IDP09811
Protein NameGlycogen phosphorylase, liver form
Gene NamePygl
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
421 RIVALFPKDIDRMRR

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MAKPLTDQEK 20 RRQISIRGIV 30 GVENVAELKK 40 GFNRHLHFTL 50 VKDRNVATPR 60 DYYFALAHTV 70 RDHLVGRWIR 80 TQQHYYDKCP 90 KRVYYLSLEF 100 YMGRTLQNTM 110 INLGLQNACD 120 EAIYQLGLDM 130 EELEEIEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEYGIFNQK 180 IREGWQVEEA 190 DDWLRHGNPW 200 EKARPEFMLP 210 VHFYGRVEHT 220 QAGTKWVDTQ 230 VVLALPYDTP 240 VPGYMNNTVN 250 TMRLWSARAP 260 NDFNLQDFNV 270 GDYIQAVLDR 280 NLAENISRVL 290 YPNDNFFEGK 300 ELRLKQEYFV 310 VAATLQDVIR 320 RFKASKFGSK 330 DGVGTVFDAF 340 PDQVAIQLND 350 THPALAIPEL 360 MRIFVDIEKL 370 PWSKAWEITK 380 KTFAYTNHTV 390 LPEALERWPV 400 DLVEKLLPRH 410 LQIIYEINQK 420 HLDRIVALFP 430 KDIDRMRRMS 440 LIEEEGGKRI 450 NMAHLCIVGC 460 HAVNGVAKIH 470 SDIVKTQVFK 480 DFSELEPDKF 490 QNKTNGITPR 500 RWLLLCNPGL 510 ADLIAEKIGE 520 DYVKDLSQLT 530 KLHSFVGDDI 540 FLREIAKVKQ 550 ENKLKFSQFL 560 EKEYKVKINP 570 SSMFDVHVKR 580 IHEYKRQLLN 590 CLHVITMYNR 600 IKKDPKKFFV 610 PRTVIIGGKA 620 APGYHMAKMI 630 IKLVTSVAEV 640 VNNDPMVGSK 650 LKVIFLENYR 660 VSLAEKVIPA 670 TDLSEQISTA 680 GTEASGTGNM 690 KFMLNGALTI 700 GTMDGANVEM 710 AEEAGEENLF 720 IFGMRVDDVA 730 ALDKKGYEAK 740 EYYEALPELK 750 LVIDQIDNGF 760 FSPNQPDLFK 770 DIINMLFYHD 780 RFKVFADYEA 790 YVKCQEKVSQ 800 LYMNQKAWNT 810 MVLRNIAASG 820 KFSSDRTIRE 830 YAKDIWNMEP 840 SDLKISLSKE 850 SSNGVNANGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0016208 AMP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0032052 bile acid binding
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0005536 D-glucose binding
Molecular Function GO:0008184 glycogen phosphorylase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0002060 purine nucleobase binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Molecular Function GO:0019842 vitamin binding
Biological Process GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0005977 glycogen metabolic process
Biological Process GO:0070266 necroptotic process
Biological Process GO:0009617 response to bacterium

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.