Overview
| Uniprot ID | P09871 |
|---|
| Protein Name | Complement C1s subcomponent |
|---|
| Gene Name | C1S |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 629 |
EKGMDSCKGDSGGAF |
Function
Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11445589, PubMed:16169853, PubMed:417728, PubMed:467643, PubMed:6271784, PubMed:6282646, PubMed:6319179, PubMed:70787, PubMed:9422791). C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens (PubMed:34155115). C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains (PubMed:11445589, PubMed:6271784). C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway (PubMed:16169853, PubMed:467643, PubMed:6282646, PubMed:6319179, PubMed:6906228, PubMed:70787, PubMed:9422791)
Protein Sequence
10
MWCIVLFSLL
20
AWVYAEPTMY
30
GEILSPNYPQ
40
AYPSEVEKSW
50
DIEVPEGYGI
60
HLYFTHLDIE
70
LSENCAYDSV
80
QIISGDTEEG
90
RLCGQRSSNN
100
PHSPIVEEFQ
110
VPYNKLQVIF
120
KSDFSNEERF
130
TGFAAYYVAT
140
DINECTDFVD
150
VPCSHFCNNF
160
IGGYFCSCPP
170
EYFLHDDMKN
180
CGVNCSGDVF
190
TALIGEIASP
200
NYPKPYPENS
210
RCEYQIRLEK
220
GFQVVVTLRR
230
EDFDVEAADS
240
AGNCLDSLVF
250
VAGDRQFGPY
260
CGHGFPGPLN
270
IETKSNALDI
280
IFQTDLTGQK
290
KGWKLRYHGD
300
PMPCPKEDTP
310
NSVWEPAKAK
320
YVFRDVVQIT
330
CLDGFEVVEG
340
RVGATSFYST
350
CQSNGKWSNS
360
KLKCQPVDCG
370
IPESIENGKV
380
EDPESTLFGS
390
VIRYTCEEPY
400
YYMENGGGGE
410
YHCAGNGSWV
420
NEVLGPELPK
430
CVPVCGVPRE
440
PFEEKQRIIG
450
GSDADIKNFP
460
WQVFFDNPWA
470
GGALINEYWV
480
LTAAHVVEGN
490
REPTMYVGST
500
SVQTSRLAKS
510
KMLTPEHVFI
520
HPGWKLLEVP
530
EGRTNFDNDI
540
ALVRLKDPVK
550
MGPTVSPICL
560
PGTSSDYNLM
570
DGDLGLISGW
580
GRTEKRDRAV
590
RLKAARLPVA
600
PLRKCKEVKV
610
EKPTADAEAY
620
VFTPNMICAG
630
GEKGMDSCKG
640
DSGGAFAVQD
650
PNDKTKFYAA
660
GLVSWGPQCG
670
TYGLYTRVKN
680
YVDWIMKTMQ
ENSTPRED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0072562 |
blood microparticle |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005602 |
complement component C1 complex |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0106139 |
symbiont cell surface |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0004252 |
serine-type endopeptidase activity |
| Biological Process |
GO:0006958 |
complement activation, classical pathway |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0006508 |
proteolysis |
Reference
PMID: N/A