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Overview

Uniprot IDP09951
Protein NameSynapsin-1
Gene NameSyn1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
134 AKYFKGKKIHGEIDI
238 QMVRLHKKLGTEEFP
281 HSGMGKVKVDNQHDF
311 AEPFIDAKYDVRVQK
318 KYDVRVQKIGQNYKA
591 QRQGPPQKPPGPAGP
632 GPAGRPTKPQLAQKP

Function

Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:11685225). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (PubMed:11867766)

Protein Sequence

10 MNYLRRRLSD 20 SNFMANLPNG 30 YMTDLQRPQP 40 PPPPPSAASP 50 GATPGSAAAS 60 AERASTAAPV 70 ASPAAPSPGS 80 SGGGGFFSSL 90 SNAVKQTTAA 100 AAATFSEQVG 110 GGSGGAGRGG 120 AAARVLLVID 130 EPHTDWAKYF 140 KGKKIHGEID 150 IKVEQAEFSD 160 LNLVAHANGG 170 FSVDMEVLRN 180 GVKVVRSLKP 190 DFVLIRQHAF 200 SMARNGDYRS 210 LVIGLQYAGI 220 PSVNSLHSVY 230 NFCDKPWVFA 240 QMVRLHKKLG 250 TEEFPLIDQT 260 FYPNHKEMLS 270 STTYPVVVKM 280 GHAHSGMGKV 290 KVDNQHDFQD 300 IASVVALTKT 310 YATAEPFIDA 320 KYDVRVQKIG 330 QNYKAYMRTS 340 VSGNWKTNTG 350 SAMLEQIAMS 360 DRYKLWVDTC 370 SEIFGGLDIC 380 AVEALHGKDG 390 RDHIIEVVGS 400 SMPLIGDHQD 410 EDKQLIVELV 420 VNKMTQALPR 430 QRDASPGRGS 440 HSQTPSPGAL 450 PLGRQTSQQP 460 AGPPAQQRPP 470 PQGGPPQPGP 480 GPQRQGPPLQ 490 QRPPPQGQQH 500 LSGLGPPAGS 510 PLPQRLPSPT 520 AAPQQSASQA 530 TPMTQGQGRQ 540 SRPVAGGPGA 550 PPAARPPASP 560 SPQRQAGPPQ 570 ATRQASISGP 580 APPKVSGASP 590 GGQQRQGPPQ 600 KPPGPAGPIR 610 QASQAGPGPR 620 TGPPTTQQPR 630 PSGPGPAGRP 640 TKPQLAQKPS 650 QDVPPPIIAA 660 AGGPPHPQLN 670 KSQSLTNAFN 680 LPEPAPPRPS 690 LSQDEVKAET 700 IRSLRKSFAS LFSD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0044297 cell body
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0030425 dendrite
Cellular Component GO:0098850 extrinsic component of synaptic vesicle membrane
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0098793 presynapse
Cellular Component GO:0048786 presynaptic active zone
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0045202 synapse
Cellular Component GO:0008021 synaptic vesicle
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0000795 synaptonemal complex
Cellular Component GO:0043195 terminal bouton
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0048666 neuron development
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0098693 regulation of synaptic vesicle cycle
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:0050808 synapse organization
Biological Process GO:0097091 synaptic vesicle clustering
Biological Process GO:0099504 synaptic vesicle cycle

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.