Search Results

Overview

Uniprot IDP09972
Protein NameFructose-bisphosphate aldolase C
Gene NameALDOC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 FVRTIQDKGIVVGIK
108 KGIVVGIKVDKGVVP
111 VVGIKVDKGVVPLAG
13 PALSAEQKKELSDIA
14 ALSAEQKKELSDIAL
147 KDGADFAKWRCVLKI
200 PDGDHDLKRCQYVTE
230 YLEGTLLKPNMVTPG
28 LRIVAPGKGILAADE
330 AATEEFIKRAEVNGL
42 ESVGSMAKRLSQIGV

Function

Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis

Protein Sequence

10 MPHSYPALSA 20 EQKKELSDIA 30 LRIVAPGKGI 40 LAADESVGSM 50 AKRLSQIGVE 60 NTEENRRLYR 70 QVLFSADDRV 80 KKCIGGVIFF 90 HETLYQKDDN 100 GVPFVRTIQD 110 KGIVVGIKVD 120 KGVVPLAGTD 130 GETTTQGLDG 140 LSERCAQYKK 150 DGADFAKWRC 160 VLKISERTPS 170 ALAILENANV 180 LARYASICQQ 190 NGIVPIVEPE 200 ILPDGDHDLK 210 RCQYVTEKVL 220 AAVYKALSDH 230 HVYLEGTLLK 240 PNMVTPGHAC 250 PIKYTPEEIA 260 MATVTALRRT 270 VPPAVPGVTF 280 LSGGQSEEEA 290 SFNLNAINRC 300 PLPRPWALTF 310 SYGRALQASA 320 LNAWRGQRDN 330 AGAATEEFIK 340 RAEVNGLAAQ 350 GKYEGSGEDG 360 GAAAQSLYIA NHAY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:1904724 tertiary granule lumen
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0004332 fructose-bisphosphate aldolase activity
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0030388 fructose 1,6-bisphosphate metabolic process
Biological Process GO:0006000 fructose metabolic process
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006096 glycolytic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.