Overview
| Uniprot ID | P0C089 |
|---|
| Protein Name | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
|---|
| Gene Name | Ptpmt1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 88 |
CNTSKEWKNVGVEQL |
Function
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (PubMed:16039589). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (PubMed:16039589). Probably involved in regulation of insulin secretion in pancreatic beta cells (PubMed:16039589). Prevents intrinsic apoptosis, by regulating mitochondrial membrane integrity (By similarity)
Protein Sequence
10
MAASAWLEAG
20
LARVLFYPTL
30
LYTVFRGRVG
40
GPAHRDWYHR
50
IDHTVLLGAL
60
PLRSMTRRLV
70
LDENVRGVIT
80
MNEEYETRFL
90
CNTSKEWKNV
100
GVEQLRLSTV
110
DMTGVPTLAN
120
LHRGVQFALK
130
YQSLGQCVYV
140
HCKAGRSRSA
150
TMVAAYLIQV
160
HNWSPEEAIE
170
AIAKIRSHIS
180
IRPSQLEILK
190
EFHKEIAARA
AKN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Molecular Function |
GO:0004725 |
protein tyrosine phosphatase activity |
| Biological Process |
GO:0032049 |
cardiolipin biosynthetic process |
| Biological Process |
GO:0043653 |
mitochondrial fragmentation involved in apoptotic process |
| Biological Process |
GO:0061179 |
negative regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process |
GO:2001242 |
regulation of intrinsic apoptotic signaling pathway |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0008962 |
phosphatidylglycerophosphatase activity |
| Molecular Function |
GO:0102091 |
phosphatidylinositol-5-phosphate phosphatase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.