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Overview

Uniprot ID	P0C0A1
Protein Name	Vacuolar protein-sorting-associated protein 25
Gene Name	Vps25
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
92	GNLEWLDKNKSSFLI

Function

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL

Protein Sequence

10 MAMSFEWPWQ 20 YRFPPFFTLQ 30 PNVDTRQKQL 40 AAWCSLVLSF 50 CRLHKQSSMT 60 VMEAQESPLF 70 NNVKLQRKLP 80 VESIQIVLEE 90 LRKKGNLEWL 100 DKNKSSFLIM 110 WRRPEEWGKL 120 IYQWVSRSGQ 130 NNSVFTLYEL 140 TSGEDTEEEE 150 FHGLDEATLL 160 RALQALQQEH 170 KAEIITVSDG RGVKFF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0000814	ESCRT II complex
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0016236	macroautophagy
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
Biological Process	GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.