Search Results

Overview

Uniprot ID	P0C0L5
Protein Name	Complement C4-B
Gene Name	C4B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1061	MRIQQFRKADGSYAA
1174	RVEASISKASSFLGE
1646	AFRLFETKITQVLHF
1655	TQVLHFTKDVKAAAN
53	VPRGQVVKGSVFLRN
579	ELSVDGAKQYRNGES
617	AAGSKSHKPLNMGKV
685	KRNVNFQKAINEKLG
690	FQKAINEKLGQYASP
700	QYASPTAKRCCQDGV
749	LRKKSRDKGQAGLQR
817	GLSLSKTKGLCVATP
935	SKVLQIEKEGAIHRE
95	QVPLKDAKSCGLHQL

Function

Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system

Protein Sequence

10 MRLLWGLIWA 20 SSFFTLSLQK 30 PRLLLFSPSV 40 VHLGVPLSVG 50 VQLQDVPRGQ 60 VVKGSVFLRN 70 PSRNNVPCSP 80 KVDFTLSSER 90 DFALLSLQVP 100 LKDAKSCGLH 110 QLLRGPEVQL 120 VAHSPWLKDS 130 LSRTTNIQGI 140 NLLFSSRRGH 150 LFLQTDQPIY 160 NPGQRVRYRV 170 FALDQKMRPS 180 TDTITVMVEN 190 SHGLRVRKKE 200 VYMPSSIFQD 210 DFVIPDISEP 220 GTWKISARFS 230 DGLESNSSTQ 240 FEVKKYVLPN 250 FEVKITPGKP 260 YILTVPGHLD 270 EMQLDIQARY 280 IYGKPVQGVA 290 YVRFGLLDED 300 GKKTFFRGLE 310 SQTKLVNGQS 320 HISLSKAEFQ 330 DALEKLNMGI 340 TDLQGLRLYV 350 AAAIIESPGG 360 EMEEAELTSW 370 YFVSSPFSLD 380 LSKTKRHLVP 390 GAPFLLQALV 400 REMSGSPASG 410 IPVKVSATVS 420 SPGSVPEVQD 430 IQQNTDGSGQ 440 VSIPIIIPQT 450 ISELQLSVSA 460 GSPHPAIARL 470 TVAAPPSGGP 480 GFLSIERPDS 490 RPPRVGDTLN 500 LNLRAVGSGA 510 TFSHYYYMIL 520 SRGQIVFMNR 530 EPKRTLTSVS 540 VFVDHHLAPS 550 FYFVAFYYHG 560 DHPVANSLRV 570 DVQAGACEGK 580 LELSVDGAKQ 590 YRNGESVKLH 600 LETDSLALVA 610 LGALDTALYA 620 AGSKSHKPLN 630 MGKVFEAMNS 640 YDLGCGPGGG 650 DSALQVFQAA 660 GLAFSDGDQW 670 TLSRKRLSCP 680 KEKTTRKKRN 690 VNFQKAINEK 700 LGQYASPTAK 710 RCCQDGVTRL 720 PMMRSCEQRA 730 ARVQQPDCRE 740 PFLSCCQFAE 750 SLRKKSRDKG 760 QAGLQRALEI 770 LQEEDLIDED 780 DIPVRSFFPE 790 NWLWRVETVD 800 RFQILTLWLP 810 DSLTTWEIHG 820 LSLSKTKGLC 830 VATPVQLRVF 840 REFHLHLRLP 850 MSVRRFEQLE 860 LRPVLYNYLD 870 KNLTVSVHVS 880 PVEGLCLAGG 890 GGLAQQVLVP 900 AGSARPVAFS 910 VVPTAATAVS 920 LKVVARGSFE 930 FPVGDAVSKV 940 LQIEKEGAIH 950 REELVYELNP 960 LDHRGRTLEI 970 PGNSDPNMIP 980 DGDFNSYVRV 990 TASDPLDTLG 1000 SEGALSPGGV 1010 ASLLRLPRGC 1020 GEQTMIYLAP 1030 TLAASRYLDK 1040 TEQWSTLPPE 1050 TKDHAVDLIQ 1060 KGYMRIQQFR 1070 KADGSYAAWL 1080 SRGSSTWLTA 1090 FVLKVLSLAQ 1100 EQVGGSPEKL 1110 QETSNWLLSQ 1120 QQADGSFQDL 1130 SPVIHRSMQG 1140 GLVGNDETVA 1150 LTAFVTIALH 1160 HGLAVFQDEG 1170 AEPLKQRVEA 1180 SISKASSFLG 1190 EKASAGLLGA 1200 HAAAITAYAL 1210 TLTKAPADLR 1220 GVAHNNLMAM 1230 AQETGDNLYW 1240 GSVTGSQSNA 1250 VSPTPAPRNP 1260 SDPMPQAPAL 1270 WIETTAYALL 1280 HLLLHEGKAE 1290 MADQAAAWLT 1300 RQGSFQGGFR 1310 STQDTVIALD 1320 ALSAYWIASH 1330 TTEERGLNVT 1340 LSSTGRNGFK 1350 SHALQLNNRQ 1360 IRGLEEELQF 1370 SLGSKINVKV 1380 GGNSKGTLKV 1390 LRTYNVLDMK 1400 NTTCQDLQIE 1410 VTVKGHVEYT 1420 MEANEDYEDY 1430 EYDELPAKDD 1440 PDAPLQPVTP 1450 LQLFEGRRNR 1460 RRREAPKVVE 1470 EQESRVHYTV 1480 CIWRNGKVGL 1490 SGMAIADVTL 1500 LSGFHALRAD 1510 LEKLTSLSDR 1520 YVSHFETEGP 1530 HVLLYFDSVP 1540 TSRECVGFEA 1550 VQEVPVGLVQ 1560 PASATLYDYY 1570 NPERRCSVFY 1580 GAPSKSRLLA 1590 TLCSAEVCQC 1600 AEGKCPRQRR 1610 ALERGLQDED 1620 GYRMKFACYY 1630 PRVEYGFQVK 1640 VLREDSRAAF 1650 RLFETKITQV 1660 LHFTKDVKAA 1670 ANQMRNFLVR 1680 ASCRLRLEPG 1690 KEYLIMGLDG 1700 ATYDLEGHPQ 1710 YLLDSNSWIE 1720 EMPSERLCRS 1730 TRQRAACAQL 1740 NDFLQEYGTQ GCQV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0030424	axon
Cellular Component	GO:0072562	blood microparticle
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0106139	symbiont cell surface
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0030246	carbohydrate binding
Molecular Function	GO:0001848	complement binding
Molecular Function	GO:0004866	endopeptidase inhibitor activity
Biological Process	GO:0006956	complement activation
Biological Process	GO:0006958	complement activation, classical pathway
Biological Process	GO:0160257	complement activation, GZMK pathway
Biological Process	GO:0032490	detection of molecule of bacterial origin
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0008228	opsonization
Biological Process	GO:2000427	positive regulation of apoptotic cell clearance

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.