Overview
| Uniprot ID | P0C0S7 |
|---|
| Protein Name | Histone H2A.Z |
|---|
| Gene Name | H2az1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 116 |
GVIPHIHKSLIGKKG |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)
Protein Sequence
10
MAGGKAGKDS
20
GKAKTKAVSR
30
SQRAGLQFPV
40
GRIHRHLKSR
50
TTSHGRVGAT
60
AAVYSAAILE
70
YLTAEVLELA
80
GNASKDLKVK
90
RITPRHLQLA
100
IRGDEELDSL
110
IKATIAGGGV
120
IPHIHKSLIG
KKGQQKTV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000791 |
euchromatin |
| Cellular Component |
GO:0000792 |
heterochromatin |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000786 |
nucleosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0031490 |
chromatin DNA binding |
| Molecular Function |
GO:0031492 |
nucleosomal DNA binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
| Molecular Function |
GO:0030527 |
structural constituent of chromatin |
| Biological Process |
GO:0071392 |
cellular response to estradiol stimulus |
| Biological Process |
GO:0032869 |
cellular response to insulin stimulus |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.