Search Results

Overview

Uniprot ID	P0C2X9
Protein Name	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Gene Name	Aldh4a1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
401	KAFARIKKWLEHARS
92	NHGHKVAKFCYADKA

Function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity)

Protein Sequence

10 MLPPALLRRS 20 LLSYAWRGSG 30 LRWKHASSLK 40 VANEPILAFT 50 QGSPERDALQ 60 KALNDLKDQT 70 EAIPCVVGDE 80 EVWTSDVRYQ 90 LSPFNHGHKV 100 AKFCYADKAL 110 LNKAIEAAVL 120 ARKEWDLKPV 130 ADRAQIFLKA 140 ADMLSGPRRA 150 EILAKTMVGQ 160 GKTVIQAEID 170 AAAELIDFFR 180 FNAKFAVELE 190 GEQPISVPPS 200 TNHVVYRGLE 210 GFVAAISPFN 220 FTAIGGNLAG 230 APALMGNVVL 240 WKPSDTAMLA 250 SYAVYRILRE 260 AGLPPNVIQF 270 VPADGPTFGD 280 TVTSSEHLCG 290 INFTGSVPTF 300 KHLWKQVAQN 310 LDRFRTFPRL 320 AGECGGKNFH 330 FVHSSADVDS 340 VVSGTLRSAF 350 EYGGQKCSAC 360 SRLYVPQSLW 370 PQIKGRLLEE 380 HSRIKVGNPA 390 EDFGTFFSAV 400 IDAKAFARIK 410 KWLEHARSSP 420 SLSILAGGQC 430 NESVGYFVEP 440 CIIESKDPQE 450 PIMKEEIFGP 460 VLTVYVYPDE 470 KYRETLQLVD 480 STTSYGLTGA 490 VFAQDKTIVQ 500 EATRMLRNAA 510 GNFYINDKST 520 GSVVGQQPFG 530 GARASGERDI 540 PGQPRLVQLW 550 TEPPFTPLAV 560 SPPLGDWRYS YMQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003842	L-glutamate gamma-semialdehyde dehydrogenase activity
Biological Process	GO:0010133	L-proline catabolic process to L-glutamate

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.