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Overview

Uniprot IDP0C522
Protein NameATP synthase subunit alpha, mitochondrial
Gene NameATPA
OrganismOryza sativa subsp. japonica

Kla Sites from experimental identification

Position Flanking peptide
120 LGVPIDGKGALSDHE
384 VGSAAQLKAMKQVCG
387 AAQLKAMKQVCGSLK
481 TINPELLKSFNEKGG
486 LLKSFNEKGGLTNER
494 GGLTNERKIELDAFL

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity)

Protein Sequence

10 MEFSPRAAEL 20 TTLLESRMTN 30 FYTNFQVDEI 40 GRVVSVGDGI 50 ARVYGLNEIQ 60 AGEMVEFASG 70 VKGIALNLEN 80 ENVGIVVFGS 90 DTAIKEGDLV 100 KRTGSIVDVP 110 AGKAMLGRVV 120 DALGVPIDGK 130 GALSDHERRR 140 VEVKAPGIIE 150 RKSVHEPMQT 160 GLKAVDSLVP 170 IGRGQRELII 180 GDRQTGKTAI 190 AIDTILNQKQ 200 MNSRGTNESE 210 TLYCVYVAIG 220 QKRSTVAQLV 230 QILSEANALE 240 YSILVAATAS 250 DPAPLQFLAP 260 YSGCAMGEYF 270 RDNGMHALII 280 YDDLSKQAVA 290 YRQMSLLLRR 300 PPGREAFPGD 310 VFYLHSRLLE 320 RAAKRSDQTG 330 AGSLTALPVI 340 ETQAGDVSAY 350 IPTNVISITD 360 GQICLETELF 370 YRGIRPAINV 380 GLSVSRVGSA 390 AQLKAMKQVC 400 GSLKLELAQY 410 REVAAFAQFG 420 SDLDAATQAL 430 LNRGARLTEV 440 SKQPQYEPLP 450 IEKQIVVIYA 460 AVNGFCDRMP 470 LDRISQYEKA 480 ILSTINPELL 490 KSFNEKGGLT 500 NERKIELDAF LKQTAKEIN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process GO:0015986 proton motive force-driven ATP synthesis

Reference

[1] Meng X, Baine JM, Yan T, Wang S. Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains.. J Agric Food Chem 69(29):8287-8297. 2021 Jul 28. PMID: 34264677.