Search Results
Overview
| Uniprot ID | P0C5I2 |
|---|---|
| Protein Name | Mannose-1-phosphate guanylyltransferase catalytic subunit beta |
| Gene Name | GMPPB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | EGSILVTKVEEPSKY |
Function
Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex (By similarity). Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids (PubMed:11082198). Can catalyze the reverse reaction in vitro (By similarity). Together with GMPPA regulates GDP-alpha-D-mannose levels (By similarity)
Protein Sequence
10
MKALILVGGY
20
GTRLRPLTLS
30
IPKPLVDFCN
40
KPILLHQVEA
50
LASAGVDHVI
60
LAVSYMSQML
70
EKEMKAQEQR
80
LGIRISMSHE
90
EEPLGTAGPL
100
ALARDLLSET
110
AEPFFVLNSD
120
VICDFPFQAM
130
VQFHRHHGQE
140
GSILVTKVEE
150
PSKYGVVVCE
160
ADTGRIHRFV
170
EKPQVFVSNK
180
INAGMYILSP
190
AVLQRIQLQP
200
TSIEKEIFPV
210
MAKEGQLYAM
220
ELQGFWMDIG
230
QPKDFLTGMC
240
LFLQSLRQKQ
250
PEQLCSGPGI
260
VGNVLVDPSA
270
RIGKNCSIGP
280
NVSLGPGVVV
290
EDGVCIRRCT
300
VLRDARIRSH
310
SWLESCIVCW
320
RCRVGQWVRM
330
ENVTVLGEDV
340
IVNDELYLNG
350
ASVLPHKSIG
360
ESVPEPGIIM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0120508 | GDP-mannose pyrophosphorylase complex |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0004475 | mannose-1-phosphate guanylyltransferase (GTP) activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0009298 | GDP-mannose biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.