Search Results
Overview
| Uniprot ID | P0C7P0 |
|---|---|
| Protein Name | CDGSH iron-sulfur domain-containing protein 3, mitochondrial |
| Gene Name | CISD3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 48 | VALKTPIKVELVAGK |
| 55 | KVELVAGKTYRWCVC |
| 67 | CVCGRSKKQPFCDGS |
Function
Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function
Protein Sequence
10
MRGAGAILRP
20
AARGARDLNP
30
RRDISSWLAQ
40
WFPRTPARSV
50
VALKTPIKVE
60
LVAGKTYRWC
70
VCGRSKKQPF
80
CDGSHFFQRT
90
GLSPLKFKAQ
100
ETRMVALCTC
110
KATQRPPYCD
120
GTHRSERVQK
AEVGSPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.