Search Results

Overview

Uniprot ID	P0C7T5
Protein Name	Ataxin-1-like
Gene Name	ATXN1L
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
389	NPAELAEKSQARGFY
405	QSHQEPVKHRPLPKA
624	ELCDSEGKSQPAGEG

Function

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity)

Protein Sequence

10 MKPVHERSQE 20 CLPPKKRDLP 30 VTSEDMGRTT 40 SCSTNHTPSS 50 DASEWSRGVV 60 VAGQSQAGAR 70 VSLGGDGAEA 80 ITGLTVDQYG 90 MLYKVAVPPA 100 TFSPTGLPSV 110 VNMSPLPPTF 120 NVASSLIQHP 130 GIHYPPLHYA 140 QLPSTSLQFI 150 GSPYSLPYAV 160 PPNFLPSPLL 170 SPSANLATSH 180 LPHFVPYASL 190 LAEGATPPPQ 200 APSPAHSFNK 210 APSATSPSGQ 220 LPHHSSTQPL 230 DLAPGRMPIY 240 YQMSRLPAGY 250 TLHETPPAGA 260 SPVLTPQESQ 270 SALEAAAANG 280 GQRPRERNLV 290 RRESEALDSP 300 NSKGEGQGLV 310 PVVECVVDGQ 320 LFSGSQTPRV 330 EVAAPAHRGT 340 PDTDLEVQRV 350 VGALASQDYR 360 VVAAQRKEEP 370 SPLNLSHHTP 380 DHQGEGRGSA 390 RNPAELAEKS 400 QARGFYPQSH 410 QEPVKHRPLP 420 KAMVVANGNL 430 VPTGTDSGLL 440 PVGSEILVAS 450 SLDVQARATF 460 PDKEPTPPPI 470 TSSHLPSHFM 480 KGAIIQLATG 490 ELKRVEDLQT 500 QDFVRSAEVS 510 GGLKIDSSTV 520 VDIQESQWPG 530 FVMLHFVVGE 540 QQSKVSIEVP 550 PEHPFFVYGQ 560 GWSSCSPGRT 570 TQLFSLPCHR 580 LQVGDVCISI 590 SLQSLNSNSV 600 SQASCAPPSQ 610 LGPPRERPER 620 TVLGSRELCD 630 SEGKSQPAGE 640 GSRVVEPSQP 650 ESGAQACWPA 660 PSFQRYSMQG 670 EEARAALLRP 680 SFIPQEVKLS IEGRSNAGK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0031208	POZ domain binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0007420	brain development
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0007612	learning
Biological Process	GO:0007613	memory
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0035176	social behavior

Reference

[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.