Overview
| Uniprot ID | P0CG13 |
|---|
| Protein Name | Chromosome transmission fidelity protein 8 homolog |
|---|
| Gene Name | CHTF8 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 119 |
PIITSVPKKV***** |
| 120 |
IITSVPKKV****** |
Function
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression
Protein Sequence
10
MVQIVISSAR
20
AGGLAEWVLM
30
ELQGEIEARY
40
STGLAGNLLG
50
DLHYTTEGIP
60
VLIVGHHILY
70
GKIIHLEKPF
80
AVLVKHTPGD
90
QDCDELGRET
100
GTRYLVTALI
110
KDKILFKTRP
120
KPIITSVPKK
V
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031390 |
Ctf18 RFC-like complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Biological Process |
GO:0006260 |
DNA replication |
| Biological Process |
GO:0007064 |
mitotic sister chromatid cohesion |
| Biological Process |
GO:1900264 |
positive regulation of DNA-directed DNA polymerase activity |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.