Search Results
Overview
| Uniprot ID | P0DJJ3 |
|---|---|
| Protein Name | SH3-containing GRB2-like protein 3-interacting protein 1 |
| Gene Name | Sgip1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | KIKPLQSKDVLKNAA |
| 131 | LQSKDVLKNAATVDE |
| 469 | PRPPSRPKLPPGKPG |
| 474 | RPKLPPGKPGVGDVS |
| 580 | FKGADPSKCIVKITG |
Function
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis
Protein Sequence
10
MMEGLKKRTR
20
KAFGIRKKEK
30
DTDSTGSPDR
40
DGMQPSPHEP
50
PYHSKAECAR
60
EGGKKASKKS
70
NGAPNGFYAE
80
IDWERYNSPE
90
LDEEGYSIRP
100
EEPGSTKGKH
110
FYSSSESEEE
120
EESHKKFNIK
130
IKPLQSKDVL
140
KNAATVDELK
150
ASIGNIALSP
160
SPVRKSPRRS
170
PGAIKRNLSS
180
EEVARPRRST
190
PTPELTSKKP
200
LDDTLALAPL
210
FGPPLESAFD
220
EQKTEVLLDQ
230
PEIWGSGQPI
240
NPSMESPKLA
250
RPFPTGTPPP
260
LPPKAVPATP
270
PRTGSPLTVA
280
TGNDQAATEA
290
KIEKLPSISD
300
LDSIFGPVLS
310
PKSVAVNTEE
320
KWVHFSDASP
330
EHVTPELTPR
340
EKVVTPPAAS
350
DIPADSPAPG
360
PPGPPGSAGP
370
PGPPGPRHVP
380
SPLNLEEVQK
390
KVAEQTFIKD
400
DYLETLSSPK
410
ECGLGQRATP
420
PPPPPPTYRT
430
VVSSPGPGSG
440
SGTGTASGAS
450
SPARPATPLV
460
PCSSTTPPPP
470
PPRPPSRPKL
480
PPGKPGVGDV
490
SRPFSPPIHS
500
SSPPPIAPLA
510
RAESTSSISS
520
TNSLSAATTP
530
TVENEQPSLV
540
WFDRGKFYLT
550
FEGSSRGPSP
560
LTMGAQDTLP
570
VAAAFTETVN
580
AYFKGADPSK
590
CIVKITGEMV
600
LSFPAGITRH
610
FANNPSPAAL
620
TFRVINSSRL
630
EHVLPNPQLL
640
CCDNTQNDAN
650
TKEFWVNMPN
660
LMTHLKKVSE
670
QKPQATYYNV
680
DMLKYQVSAQ
690
GIQSTPLNLA
700
VNWRCEPGST
710
DLRIDYKYNT
720
DAMTTAVALN
730
NVQFLVPIDG
740
GVTKLQAVLP
750
PAVWNAEQQR
760
ILWKIPDISQ
770
KSENGGVGSL
780
LARFQLSEGP
790
SKPSPLVVQF
800
TSEGSTLSGC
810
DIELVGAGYR
820
FSLIKKRFAA
GKYLADN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030122 | AP-2 adaptor complex |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0030136 | clathrin-coated vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0072583 | clathrin-dependent endocytosis |
| Biological Process | GO:0097009 | energy homeostasis |
| Biological Process | GO:0097320 | plasma membrane tubulation |
| Biological Process | GO:1904000 | positive regulation of eating behavior |
| Biological Process | GO:2000253 | positive regulation of feeding behavior |
| Biological Process | GO:0040018 | positive regulation of multicellular organism growth |
| Biological Process | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| Biological Process | GO:0002021 | response to dietary excess |
| Biological Process | GO:0042594 | response to starvation |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.