Overview
| Uniprot ID | P0DOV2 |
|---|
| Protein Name | Interferon-activable protein 204 |
|---|
| Gene Name | Ifi204 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 210 |
IPSAKNQKSQPQNQN |
Function
Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity (PubMed:16244109, PubMed:25710914, PubMed:30936875). Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway (PubMed:25710914, PubMed:33619523). Mechanistically, gets acetylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release (PubMed:28529930). Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation
Protein Sequence
10
MVNEYKRIVL
20
LRGLECINKH
30
YFSLFKSLLA
40
RDLNLERDNQ
50
EQYTTIQIAN
60
MMEEKFPADS
70
GLGKLIAFCE
80
EVPALRKRAE
90
ILKKERSEVT
100
GETSLEKNGQ
110
EAGPATPTST
120
TSHMLASERG
130
ETSATQEETS
140
TAQAGTSTAQ
150
ARTSTAQAGT
160
STAQKRKIMR
170
EEETGVKKSK
180
AAKEPDQPPC
190
CEEPTARCQS
200
PILHSSSSAS
210
SNIPSAKNQK
220
SQPQNQNIPR
230
GAVLHSEPLT
240
VMVLTATDPF
250
EYESPEHEVK
260
NMLHATVATV
270
SQYFHVKVFN
280
INLKEKFTKK
290
NFIIISNYFE
300
SKGILEINET
310
SSVLEAAPDQ
320
MIEVPNSIIR
330
NANASPKICD
340
IQKGTSGAVF
350
YGVFTLHKKT
360
VNRKNTIYEI
370
KDGSGSIEVV
380
GSGKWHNINC
390
KEGDKLHLFC
400
FHLKTIDRQP
410
KLVCGEHSFI
420
KISKRGNVPK
430
EPAKEEDHHH
440
GPKQVMVLKV
450
TEPFTYDLKE
460
DKRMFHATVA
470
TETEFFRVKV
480
FDTALKSKFI
490
PRNIIAISDY
500
FGCNGFLEIY
510
RASCVSDVNV
520
NPTMVISNTL
530
RQRANATPKI
540
SYLFSQARGT
550
FVSGEYLVNK
560
KTERNKFIYY
570
GIGDDTGKME
580
VVVYGRLTNV
590
RCEPGSKLRL
600
VCFELTSTED
610
GWQLRSVRHS
YMQVINARK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0042405 |
nuclear inclusion body |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0003690 |
double-stranded DNA binding |
| Molecular Function |
GO:0003712 |
transcription coregulator activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0002218 |
activation of innate immune response |
| Biological Process |
GO:0035457 |
cellular response to interferon-alpha |
| Biological Process |
GO:0035458 |
cellular response to interferon-beta |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0048839 |
inner ear development |
| Biological Process |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process |
GO:0045669 |
positive regulation of osteoblast differentiation |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0009617 |
response to bacterium |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.