Overview
| Uniprot ID | P0DOX2 |
|---|
| Protein Name | Immunoglobulin alpha-2 heavy chain |
|---|
| Gene Name | - |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 360 |
LARGFSPKDVLVRWL |
| 377 |
SQELPREKYLTWASR |
Function
Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915)
Protein Sequence
10
EVQLVETGGG
20
LIQPGGSLRL
30
SCAASGFTVS
40
NHSMSWVRQA
50
PGKALEWVSA
60
IYRGGTTYYA
70
DSVKGRFTIS
80
RDDSRNTVYL
90
QMNSLRAEDT
100
AVYYCARDLA
110
AARLFGKGTT
120
VTVSSASPTS
130
PKVFPLSLDS
140
TPQDGNVVVA
150
CLVQGFFPQE
160
PLSVTWSESG
170
QNVTARNFPP
180
SQDASGDLYT
190
TSSQLTLPAT
200
QCPDGKSVTC
210
HVKHYTNSSQ
220
DVTVPCRVPP
230
PPPCCHPRLS
240
LHRPALEDLL
250
LGSEANLTCT
260
LTGLRDASGA
270
TFTWTPSSGK
280
SAVEGPPERD
290
LCGCYSVSSV
300
LPGCAQPWNH
310
GETFTCTAAH
320
PELKTPLTAN
330
ITKSGNTFRP
340
EVHLLPPPSE
350
ELALNELVTL
360
TCLARGFSPK
370
DVLVRWLQGS
380
QELPREKYLT
390
WASRQEPSQG
400
TTTYAVTSIL
410
RVAAEDWKKG
420
ETFSCMVGHE
430
ALPLAFTQKT
440
IDRLAGKPTH
450
INVSVVMAEA
DGTCY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071748 |
monomeric IgA immunoglobulin complex |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0071752 |
secretory dimeric IgA immunoglobulin complex |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0019731 |
antibacterial humoral response |
| Biological Process |
GO:0003094 |
glomerular filtration |
| Biological Process |
GO:0060267 |
positive regulation of respiratory burst |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.