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Overview

Uniprot IDP0DOX5
Protein NameImmunoglobulin gamma-1 heavy chain
Gene Name-
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
135 FPLAPSSKSTSGGTA
220 VDKKVEPKSCDKTHT
224 VEPKSCDKTHTCPPC
248 SVFLFPPKPKDTLMI
250 FLFPPKPKDTLMISR
290 GVEVHNAKTKPREEQ
319 HQDWLNGKEYKCKVS
328 YKCKVSNKALPAPIE
336 ALPAPIEKTISKAKG
362 PSRDELTKNQVSLTC
416 YSKLTVDKSRWQQGN

Function

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414, PubMed:24626930, PubMed:29449492). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)

Protein Sequence

10 QVQLVQSGGG 20 VVQPGRSLRL 30 SCAASGFTFS 40 RYTIHWVRQA 50 PGKGLEWVAV 60 MSYNGNNKHY 70 ADSVNGRFTI 80 SRNDSKNTLY 90 LNMNSLRPED 100 TAVYYCARIR 110 DTAMFFAHWG 120 QGTLVTVSSA 130 STKGPSVFPL 140 APSSKSTSGG 150 TAALGCLVKD 160 YFPEPVTVSW 170 NSGALTSGVH 180 TFPAVLQSSG 190 LYSLSSVVTV 200 PSSSLGTQTY 210 ICNVNHKPSN 220 TKVDKKVEPK 230 SCDKTHTCPP 240 CPAPELLGGP 250 SVFLFPPKPK 260 DTLMISRTPE 270 VTCVVVDVSH 280 EDPEVKFNWY 290 VDGVEVHNAK 300 TKPREEQYNS 310 TYRVVSVLTV 320 LHQDWLNGKE 330 YKCKVSNKAL 340 PAPIEKTISK 350 AKGQPREPQV 360 YTLPPSRDEL 370 TKNQVSLTCL 380 VKGFYPSDIA 390 VEWESNGQPE 400 NNYKTTPPVL 410 DSDGSFFLYS 420 KLTVDKSRWQ 430 QGNVFSCSVM 440 HEALHNHYTQ KSLSLSPGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0019814 immunoglobulin complex
Cellular Component GO:0005886 plasma membrane
Biological Process GO:0002250 adaptive immune response

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Hu J, Jin Z, Gao Y, Liu Q, Yu Y et al.. Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.. J Proteome Res 24(4):1732-1744. 2025 Apr 4. PMID: 40112136.