Search Results

Overview

Uniprot ID	P0DOX8
Protein Name	Immunoglobulin lambda-1 light chain
Gene Name	-
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
160	KADGSPVKAGVETTK
175	PSKQSNNKYAASSYL

Function

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)

Protein Sequence

10 QSALTQPPSA 20 SGSLGQSVTI 30 SCTGTSSDVG 40 GYNYVSWYQQ 50 HAGKAPKVII 60 YEVNKRPSGV 70 PDRFSGSKSG 80 NTASLTVSGL 90 QAEDEADYYC 100 SSYEGSDNFV 110 FGTGTKVTVL 120 GQPKANPTVT 130 LFPPSSEELQ 140 ANKATLVCLI 150 SDFYPGAVTV 160 AWKADGSPVK 170 AGVETTKPSK 180 QSNNKYAASS 190 YLSLTPEQWK 200 SHRSYSCQVT 210 HEGSTVEKTV APTECS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0019814	immunoglobulin complex
Cellular Component	GO:0005886	plasma membrane
Biological Process	GO:0002250	adaptive immune response

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.