Search Results

Overview

Uniprot ID	P0DP01
Protein Name	Immunoglobulin heavy variable 1-8
Gene Name	IGHV1-8
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
32	QSGAEVKKPGASVKV
38	KKPGASVKVSCKASG

Function

V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)

Protein Sequence

10 MDWTWRILFL 20 VAAATSAHSQ 30 VQLVQSGAEV 40 KKPGASVKVS 50 CKASGYTFTS 60 YDINWVRQAT 70 GQGLEWMGWM 80 NPNSGNTGYA 90 QKFQGRVTMT 100 RNTSISTAYM 110 ELSSLRSEDT AVYYCAR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0019814	immunoglobulin complex
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0003823	antigen binding
Biological Process	GO:0016064	immunoglobulin mediated immune response

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.