Overview
| Uniprot ID | P0DP24 |
|---|
| Protein Name | Calmodulin-2 |
|---|
| Gene Name | CALM2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 78 |
TMMARKMKDTDSEEE |
| 95 |
EAFRVFDKDGNGYIS |
Function
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:26969752, PubMed:27165696). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696)
Protein Sequence
10
MADQLTEEQI
20
AEFKEAFSLF
30
DKDGDGTITT
40
KELGTVMRSL
50
GQNPTEAELQ
60
DMINEVDADG
70
NGTIDFPEFL
80
TMMARKMKDT
90
DSEEEIREAF
100
RVFDKDGNGY
110
ISAAELRHVM
120
TNLGEKLTDE
130
EVDEMIREAD
140
IDGDGQVNYE
EFVQMMTAK
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0051592 |
response to calcium ion |
| Cellular Component |
GO:0034704 |
calcium channel complex |
| Cellular Component |
GO:0044305 |
calyx of Held |
| Cellular Component |
GO:1902494 |
catalytic complex |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0043209 |
myelin sheath |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0099523 |
presynaptic cytosol |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Cellular Component |
GO:0097225 |
sperm midpiece |
| Cellular Component |
GO:0005876 |
spindle microtubule |
| Cellular Component |
GO:0000922 |
spindle pole |
| Cellular Component |
GO:0031982 |
vesicle |
| Cellular Component |
GO:0008076 |
voltage-gated potassium channel complex |
| Molecular Function |
GO:0010856 |
adenylate cyclase activator activity |
| Molecular Function |
GO:0008179 |
adenylate cyclase binding |
| Molecular Function |
GO:0019855 |
calcium channel inhibitor activity |
| Molecular Function |
GO:0005246 |
calcium channel regulator activity |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0048306 |
calcium-dependent protein binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0072542 |
protein phosphatase activator activity |
| Molecular Function |
GO:0043539 |
protein serine/threonine kinase activator activity |
| Molecular Function |
GO:0031432 |
titin binding |
| Molecular Function |
GO:0044325 |
transmembrane transporter binding |
| Molecular Function |
GO:0141110 |
transporter inhibitor activity |
| Biological Process |
GO:0097720 |
calcineurin-mediated signaling |
| Biological Process |
GO:0005513 |
detection of calcium ion |
| Biological Process |
GO:0007186 |
G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0060291 |
long-term synaptic potentiation |
| Biological Process |
GO:1905913 |
negative regulation of calcium ion export across plasma membrane |
| Biological Process |
GO:0060315 |
negative regulation of ryanodine-sensitive calcium-release channel activity |
| Biological Process |
GO:0140238 |
presynaptic endocytosis |
| Biological Process |
GO:0050848 |
regulation of calcium-mediated signaling |
| Biological Process |
GO:0055117 |
regulation of cardiac muscle contraction |
| Biological Process |
GO:0010881 |
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process |
GO:1901844 |
regulation of cell communication by electrical coupling involved in cardiac conduction |
| Biological Process |
GO:0032465 |
regulation of cytokinesis |
| Biological Process |
GO:0002027 |
regulation of heart rate |
| Biological Process |
GO:0010880 |
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process |
GO:0021762 |
substantia nigra development |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.