Search Results
Overview
| Uniprot ID | P0DP25 |
|---|---|
| Protein Name | Calmodulin-3 |
| Gene Name | CALM3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | EEQIAEFKEAFSLFD |
| 22 | EAFSLFDKDGDGTIT |
| 31 | GDGTITTKELGTVMR |
| 78 | TMMARKMKDTDSEEE |
| 95 | EAFRVFDKDGNGYIS |
Function
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034704 | calcium channel complex |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0141110 | transporter inhibitor activity |
| Molecular Function | GO:0031800 | type 3 metabotropic glutamate receptor binding |
| Biological Process | GO:0097720 | calcineurin-mediated signaling |
| Biological Process | GO:0005513 | detection of calcium ion |
| Biological Process | GO:0090151 | establishment of protein localization to mitochondrial membrane |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:1905913 | negative regulation of calcium ion export across plasma membrane |
| Biological Process | GO:1901842 | negative regulation of high voltage-gated calcium channel activity |
| Biological Process | GO:0140238 | presynaptic endocytosis |
| Biological Process | GO:0098901 | regulation of cardiac muscle cell action potential |
| Biological Process | GO:0055117 | regulation of cardiac muscle contraction |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction |
| Biological Process | GO:0032465 | regulation of cytokinesis |
| Biological Process | GO:0002027 | regulation of heart rate |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:1900242 | regulation of synaptic vesicle endocytosis |
| Biological Process | GO:2000300 | regulation of synaptic vesicle exocytosis |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0051412 | response to corticosterone |
| Biological Process | GO:0021762 | substantia nigra development |
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:1902494 | catalytic complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0005876 | spindle microtubule |
| Cellular Component | GO:0000922 | spindle pole |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0008076 | voltage-gated potassium channel complex |
| Molecular Function | GO:0010856 | adenylate cyclase activator activity |
| Molecular Function | GO:0008179 | adenylate cyclase binding |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0030235 | nitric-oxide synthase regulator activity |
| Molecular Function | GO:0043548 | phosphatidylinositol 3-kinase binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0072542 | protein phosphatase activator activity |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Molecular Function | GO:0031432 | titin binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.