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Overview

Uniprot IDP0DP26
Protein NameCalmodulin-1
Gene NameCalm1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
78 TMMARKMKDTDSEEE
95 EAFRVFDKDGNGYIS

Function

Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (By similarity). Calcium-binding is required for the activation of calmodulin (By similarity). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). Is a regulator of voltage-dependent L-type calcium channels (By similarity). Mediates calcium-dependent inactivation of CACNA1C (By similarity). Positively regulates calcium-activated potassium channel activity of KCNN2 (By similarity). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (By similarity). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (By similarity). Component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex required to turn off the mitochondrial stress response after a specific stress event has been resolved (By similarity)

Protein Sequence

10 MADQLTEEQI 20 AEFKEAFSLF 30 DKDGDGTITT 40 KELGTVMRSL 50 GQNPTEAELQ 60 DMINEVDADG 70 NGTIDFPEFL 80 TMMARKMKDT 90 DSEEEIREAF 100 RVFDKDGNGY 110 ISAAELRHVM 120 TNLGEKLTDE 130 EVDEMIREAD 140 IDGDGQVNYE EFVQMMTAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034704 calcium channel complex
Cellular Component GO:0044305 calyx of Held
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030426 growth cone
Cellular Component GO:0031966 mitochondrial membrane
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0099524 postsynaptic cytosol
Cellular Component GO:0099523 presynaptic cytosol
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0097225 sperm midpiece
Cellular Component GO:0005876 spindle microtubule
Cellular Component GO:0000922 spindle pole
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0008076 voltage-gated potassium channel complex
Molecular Function GO:0010856 adenylate cyclase activator activity
Molecular Function GO:0008179 adenylate cyclase binding
Molecular Function GO:0019855 calcium channel inhibitor activity
Molecular Function GO:0005246 calcium channel regulator activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0050998 nitric-oxide synthase binding
Molecular Function GO:0030235 nitric-oxide synthase regulator activity
Molecular Function GO:0043548 phosphatidylinositol 3-kinase binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0072542 protein phosphatase activator activity
Molecular Function GO:0043539 protein serine/threonine kinase activator activity
Molecular Function GO:0031432 titin binding
Molecular Function GO:0044325 transmembrane transporter binding
Molecular Function GO:0031800 type 3 metabotropic glutamate receptor binding
Biological Process GO:0016240 autophagosome membrane docking
Biological Process GO:0097720 calcineurin-mediated signaling
Biological Process GO:0007259 cell surface receptor signaling pathway via JAK-STAT
Biological Process GO:0035458 cellular response to interferon-beta
Biological Process GO:0071346 cellular response to type II interferon
Biological Process GO:0005513 detection of calcium ion
Biological Process GO:0090151 establishment of protein localization to mitochondrial membrane
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering
Biological Process GO:1901842 negative regulation of high voltage-gated calcium channel activity
Biological Process GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0140056 organelle localization by membrane tethering
Biological Process GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:0140238 presynaptic endocytosis
Biological Process GO:0098901 regulation of cardiac muscle cell action potential
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0032465 regulation of cytokinesis
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:1900242 regulation of synaptic vesicle endocytosis
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0051412 response to corticosterone

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.