Search Results
Overview
| Uniprot ID | P0DP31 |
|---|---|
| Protein Name | Calmodulin-3 |
| Gene Name | Calm3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 22 | EAFSLFDKDGDGTIT |
| 31 | GDGTITTKELGTVMR |
| 78 | TMMARKMKDTDSEEE |
| 95 | EAFRVFDKDGNGYIS |
Function
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis
Protein Sequence
10
MADQLTEEQI
20
AEFKEAFSLF
30
DKDGDGTITT
40
KELGTVMRSL
50
GQNPTEAELQ
60
DMINEVDADG
70
NGTIDFPEFL
80
TMMARKMKDT
90
DSEEEIREAF
100
RVFDKDGNGY
110
ISAAELRHVM
120
TNLGEKLTDE
130
EVDEMIREAD
140
IDGDGQVNYE
EFVQMMTAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034704 | calcium channel complex |
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:1902494 | catalytic complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0005876 | spindle microtubule |
| Cellular Component | GO:0000922 | spindle pole |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0008076 | voltage-gated potassium channel complex |
| Molecular Function | GO:0010856 | adenylate cyclase activator activity |
| Molecular Function | GO:0008179 | adenylate cyclase binding |
| Molecular Function | GO:0019855 | calcium channel inhibitor activity |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0030235 | nitric-oxide synthase regulator activity |
| Molecular Function | GO:0043548 | phosphatidylinositol 3-kinase binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0072542 | protein phosphatase activator activity |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Molecular Function | GO:0031432 | titin binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0141110 | transporter inhibitor activity |
| Molecular Function | GO:0031800 | type 3 metabotropic glutamate receptor binding |
| Biological Process | GO:0016240 | autophagosome membrane docking |
| Biological Process | GO:0097720 | calcineurin-mediated signaling |
| Biological Process | GO:0035458 | cellular response to interferon-beta |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0005513 | detection of calcium ion |
| Biological Process | GO:0090150 | establishment of protein localization to membrane |
| Biological Process | GO:0090151 | establishment of protein localization to mitochondrial membrane |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:1990456 | mitochondrion-endoplasmic reticulum membrane tethering |
| Biological Process | GO:1905913 | negative regulation of calcium ion export across plasma membrane |
| Biological Process | GO:1901842 | negative regulation of high voltage-gated calcium channel activity |
| Biological Process | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity |
| Biological Process | GO:0140056 | organelle localization by membrane tethering |
| Biological Process | GO:0051000 | positive regulation of nitric-oxide synthase activity |
| Biological Process | GO:0046427 | positive regulation of receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0140238 | presynaptic endocytosis |
| Biological Process | GO:0050848 | regulation of calcium-mediated signaling |
| Biological Process | GO:0098901 | regulation of cardiac muscle cell action potential |
| Biological Process | GO:0055117 | regulation of cardiac muscle contraction |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction |
| Biological Process | GO:0032465 | regulation of cytokinesis |
| Biological Process | GO:0002027 | regulation of heart rate |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity |
| Biological Process | GO:1901339 | regulation of store-operated calcium channel activity |
| Biological Process | GO:1900242 | regulation of synaptic vesicle endocytosis |
| Biological Process | GO:2000300 | regulation of synaptic vesicle exocytosis |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0051412 | response to corticosterone |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.