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Overview

Uniprot IDP0DP91
Protein NameChimeric ERCC6-PGBD3 protein
Gene NameERCC6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
181 VKRQKYNKEQQLKKI
323 KKARVLSKKEERLKK
345 RALQFQGKVGLPKAR

Function

Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF

Protein Sequence

10 MPNEGIPHSS 20 QTQEQDCLQS 30 QPVSNNEEMA 40 IKQESGGDGE 50 VEEYLSFRSV 60 GDGLSTSAVG 70 CASAAPRRGP 80 ALLHIDRHQI 90 QAVEPSAQAL 100 ELQGLGVDVY 110 DQDVLEQGVL 120 QQVDNAIHEA 130 SRASQLVDVE 140 KEYRSVLDDL 150 TSCTTSLRQI 160 NKIIEQLSPQ 170 AATSRDINRK 180 LDSVKRQKYN 190 KEQQLKKITA 200 KQKHLQAILG 210 GAEVKIELDH 220 ASLEEDAEPG 230 PSSLGSMLMP 240 VQETAWEELI 250 RTGQMTPFGT 260 QIPQKQEKKP 270 RKIMLNEASG 280 FEKYLADQAK 290 LSFERKKQGC 300 NKRAARKAPA 310 PVTPPAPVQN 320 KNKPNKKARV 330 LSKKEERLKK 340 HIKKLQKRAL 350 QFQGKVGLPK 360 ARRPWESDMR 370 PEAEGDSEGE 380 ESEYFPTEEE 390 EEEEDDEVEG 400 AEADLSGDGT 410 DYELKPLPKG 420 GKRQKKVPVQ 430 EIDDDFFPSS 440 GEEAEAASVG 450 EGGGGGRKVG 460 RYRDDGDEDY 470 YKQRLSPKMP 480 RTLSLHEITD 490 LLETDDSIEA 500 SAIVIQPPEN 510 ATAPVSDEES 520 GDEEGGTINN 530 LPGSLLHTAA 540 YLIQDGSDAE 550 SDSDDPSYAP 560 KDDSPDEVPS 570 TFTVQQPPPS 580 RRRKMTKILC 590 KWKKADLTVQ 600 PVAGRVTAPP 610 NDFFTVMRTP 620 TEILELFLDD 630 EVIELIVKYS 640 NLYACSKGVH 650 LGLTSSEFKC 660 FLGIIFLSGY 670 VSVPRRRMFW 680 EQRTDVHNVL 690 VSAAMRRDRF 700 ETIFSNLHVA 710 DNANLDPVDK 720 FSKLRPLISK 730 LNERCMKFVP 740 NETYFSFDEF 750 MVPYFGRHGC 760 KQFIRGKPIR 770 FGYKFWCGAT 780 CLGYICWFQP 790 YQGKNPNTKH 800 EEYGVGASLV 810 LQFSEALTEA 820 HPGQYHFVFN 830 NFFTSIALLD 840 KLSSMGHQAT 850 GTVRKDHIDR 860 VPLESDVALK 870 KKERGTFDYR 880 IDGKGNIVCR 890 WNDNSVVTVA 900 SSGAGIHPLC 910 LVSRYSQKLK 920 KKIQVQQPNM 930 IKVYNQFMGG 940 VDRADENIDK 950 YRASIRGKKW 960 YSSPLLFCFE 970 LVLQNAWQLH 980 KTYDEKPVDF 990 LEFRRRVVCH 1000 YLETHGHPPE 1010 PGQKGRPQKR 1020 NIDSRYDGIN 1030 HVIVKQGKQT 1040 RCAECHKNTT 1050 FRCEKCDVAL 1060 HVKCSVEYHT E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0043565 sequence-specific DNA binding
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:0045739 positive regulation of DNA repair
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.