Search Results
Overview
| Uniprot ID | P0DPB6 |
|---|---|
| Protein Name | DNA-directed RNA polymerases I and III subunit RPAC2 |
| Gene Name | POLR1D |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 24 | SMAEGERKTALEMVQ |
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively
Protein Sequence
10
MEEDQELERK
20
ISGLKTSMAE
30
GERKTALEMV
40
QAAGTDRHCV
50
TFVLHEEDHT
60
LGNSLRYMIM
70
KNPEVEFCGY
80
TTTHPSESKI
90
NLRIQTRGTL
100
PAVEPFQRGL
110
NELMNVCQHV
120
LDKFEASIKD
130
YKDQKASRNE
STF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005736 | RNA polymerase I complex |
| Cellular Component | GO:0005666 | RNA polymerase III complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003899 | DNA-directed RNA polymerase activity |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Biological Process | GO:0042790 | nucleolar large rRNA transcription by RNA polymerase I |
| Biological Process | GO:0006363 | termination of RNA polymerase I transcription |
| Biological Process | GO:0006386 | termination of RNA polymerase III transcription |
| Biological Process | GO:0006383 | transcription by RNA polymerase III |
| Biological Process | GO:0006362 | transcription elongation by RNA polymerase I |
| Biological Process | GO:0006361 | transcription initiation at RNA polymerase I promoter |
| Biological Process | GO:0006384 | transcription initiation at RNA polymerase III promoter |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.