Search Results
Overview
| Uniprot ID | P0DPH7 |
|---|---|
| Protein Name | Tubulin alpha-3C chain |
| Gene Name | TUBA3C |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 124 | LVLDRIRKLADLCTG |
| 311 | KCDPRHGKYMACCML |
| 326 | YRGDVVPKDVNAAIA |
| 336 | NAAIATIKTKRTIQF |
| 338 | AIATIKTKRTIQFVD |
| 370 | VPGGDLAKVQRAVCM |
| 394 | AWARLDHKFDLMYAK |
| 401 | KFDLMYAKRAFVHWY |
| 96 | PEQLITGKEDAANNY |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Protein Sequence
10
MRECISIHVG
20
QAGVQIGNAC
30
WELYCLEHGI
40
QPDGQMPSDK
50
TIGGGDDSFN
60
TFFSETGAGK
70
HVPRAVFVDL
80
EPTVVDEVRT
90
GTYRQLFHPE
100
QLITGKEDAA
110
NNYARGHYTI
120
GKEIVDLVLD
130
RIRKLADLCT
140
GLQGFLIFHS
150
FGGGTGSGFA
160
SLLMERLSVD
170
YGKKSKLEFA
180
IYPAPQVSTA
190
VVEPYNSILT
200
THTTLEHSDC
210
AFMVDNEAIY
220
DICRRNLDIE
230
RPTYTNLNRL
240
IGQIVSSITA
250
SLRFDGALNV
260
DLTEFQTNLV
270
PYPRIHFPLA
280
TYAPVISAEK
290
AYHEQLSVAE
300
ITNACFEPAN
310
QMVKCDPRHG
320
KYMACCMLYR
330
GDVVPKDVNA
340
AIATIKTKRT
350
IQFVDWCPTG
360
FKVGINYQPP
370
TVVPGGDLAK
380
VQRAVCMLSN
390
TTAIAEAWAR
400
LDHKFDLMYA
410
KRAFVHWYVG
420
EGMEEGEFSE
430
AREDLAALEK
440
DYEEVGVDSV
450
EAEAEEGEEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005929 | cilium |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0005634 | nucleus |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.